{"id":57472,"date":"2024-07-22T12:03:38","date_gmt":"2024-07-22T12:03:38","guid":{"rendered":"https:\/\/english.saigonbiz.com.vn\/2024\/07\/22\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/"},"modified":"2024-07-22T12:03:38","modified_gmt":"2024-07-22T12:03:38","slug":"nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency","status":"publish","type":"post","link":"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/","title":{"rendered":"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency"},"content":{"rendered":"<div>\n<p><span class=\"xn-location\">SHANGHAI<\/span>, <span class=\"xn-chron\">July 22, 2024<\/span> \/PRNewswire\/ &#8212; The molecular design strategy and experimental results of Bright Gene&#8217;s dual GLP-1\/GIP receptor agonist, BGM0504, have been published online in Scientific Reports, a sub-journal of Nature, on <span class=\"xn-chron\">July 19, 2024<\/span>. Bright Gene (Stock Code: 688166.SH) is an innovative pharmaceutical company emerging on the international stage, is focused on developing best-in-class pharmaceuticals to improve patient health globally.<\/p>\n<p>The article, titled &#8220;Molecular Dynamics Guided Optimization of BGM0504 Enhances Dual Target Agonism for Combating Diabetes and Obesity&#8221;, presents the findings of BGM0504&#8217;s development.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder8646\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"><a href=\"https:\/\/mma.prnasia.com\/media2\/2465919\/image_5031720_25221542.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2465919\/image_5031720_25221542.jpg?p=medium600\" title=\"\" alt=\"\"><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>BGM0504, an AI-assisted designed dual GIP and GLP-1 receptor agonist, demonstrates superior efficacy\u00a0in both <i>in vitro<\/i> and <i>in vivo<\/i> experiments. Using AI-driven computer simulations, Bright Gene has discovered that optimal interaction between the glutamate residues on both GLP-1R and GIPR and the K20 residue of a peptide agonist provide superior activity. This interaction is a key insight not evident in cryo-EM studies. BGM0504 was designed to preserve the free amino group of the K20 residue by shifting the acylation point to position 40 of BGM0504. This design resulted in a 3-fold increase in agonistic effects on GLP-1R and GIPR, with superior therapeutic outcomes in diabetic and obesity mouse models.<\/p>\n<p><b>About Bright Gene and BGM0504<\/b><\/p>\n<p>Bright Gene (Stock Code: 688166.SH) is an innovative pharmaceutical company focused on developing best-in-class pharmaceuticals. The company integrates APIs and formulations, combining generic and innovative drugs to meet global clinical needs. BGM0504 is a dual GIP\/GLP-1 receptor agonist for treating type 2 diabetes, obesity, and NASH, currently in the late stages of Phase II clinical trials.<\/p>\n<p><b>Reference<\/b><\/p>\n<p>Yuan, J., Liu, W., Jiang, X. et al. Molecular dynamics-guided optimization of BGM0504 enhances dual-target agonism for combating diabetes and obesity. Sci Rep 14, 16680 (2024). <a href=\"https:\/\/doi.org\/10.1038\/s41598-024-66998-8\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1038\/s41598-024-66998-8<\/a><\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">  <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>SHANGHAI, July 22, 2024 \/PRNewswire\/ &#8212; The molecular design strategy and experimental results of Bright Gene&#8217;s dual GLP-1\/GIP receptor agonist, BGM0504, have been published online in Scientific Reports, a sub-journal of Nature, on July 19, 2024. Bright Gene (Stock Code: 688166.SH) is an innovative pharmaceutical company emerging on the international stage, is focused on developing [&#8230;]\n","protected":false},"author":1,"featured_media":79226,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-57472","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.6 (Yoast SEO v21.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency - Biz and Live in Saigon<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency\" \/>\n<meta property=\"og:description\" content=\"SHANGHAI, July 22, 2024 \/PRNewswire\/ &#8212; The molecular design strategy and experimental results of Bright Gene&#8217;s dual GLP-1\/GIP receptor ago\" \/>\n<meta property=\"og:url\" content=\"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/\" \/>\n<meta property=\"og:site_name\" content=\"Biz and Live in Saigon\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SaigonbizGroup\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-22T12:03:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mma.prnasia.com\/media2\/2465919\/image_5031720_25221542.jpg?p=medium600\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/267b348e6cf32a66aab33637c2d399a6\"},\"headline\":\"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency\",\"datePublished\":\"2024-07-22T12:03:38+00:00\",\"dateModified\":\"2024-07-22T12:03:38+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/\"},\"wordCount\":300,\"publisher\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#organization\"},\"articleSection\":[\"Pr Newswire\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/\",\"url\":\"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/\",\"name\":\"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency - Biz and Live in Saigon\",\"isPartOf\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#website\"},\"datePublished\":\"2024-07-22T12:03:38+00:00\",\"dateModified\":\"2024-07-22T12:03:38+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/english.saigonbiz.com\/vn\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#website\",\"url\":\"https:\/\/english.saigonbiz.com\/vn\/\",\"name\":\"Biz and Live in Saigon\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/english.saigonbiz.com\/vn\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#organization\",\"name\":\"SaigonBiz Media\",\"url\":\"https:\/\/english.saigonbiz.com\/vn\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2026\/03\/cropped-c2adea16-1c71-4315-8801-803a8d237e2a_removalai_preview.png\",\"contentUrl\":\"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2026\/03\/cropped-c2adea16-1c71-4315-8801-803a8d237e2a_removalai_preview.png\",\"width\":512,\"height\":512,\"caption\":\"SaigonBiz Media\"},\"image\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/SaigonbizGroup\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/267b348e6cf32a66aab33637c2d399a6\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2026\/03\/c2adea16-1c71-4315-8801-803a8d237e2a_removalai_preview-2_uwp_avatar_thumb.png\",\"contentUrl\":\"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2026\/03\/c2adea16-1c71-4315-8801-803a8d237e2a_removalai_preview-2_uwp_avatar_thumb.png\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/english.saigonbiz.com\/vn\"],\"url\":\"https:\/\/english.saigonbiz.com\/vn\/profile\/admin\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency - Biz and Live in Saigon","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/","og_locale":"en_US","og_type":"article","og_title":"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency","og_description":"SHANGHAI, July 22, 2024 \/PRNewswire\/ &#8212; The molecular design strategy and experimental results of Bright Gene&#8217;s dual GLP-1\/GIP receptor ago","og_url":"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/","og_site_name":"Biz and Live in Saigon","article_publisher":"https:\/\/www.facebook.com\/SaigonbizGroup","article_published_time":"2024-07-22T12:03:38+00:00","og_image":[{"url":"https:\/\/mma.prnasia.com\/media2\/2465919\/image_5031720_25221542.jpg?p=medium600"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/#article","isPartOf":{"@id":"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/"},"author":{"name":"admin","@id":"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/267b348e6cf32a66aab33637c2d399a6"},"headline":"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency","datePublished":"2024-07-22T12:03:38+00:00","dateModified":"2024-07-22T12:03:38+00:00","mainEntityOfPage":{"@id":"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/"},"wordCount":300,"publisher":{"@id":"https:\/\/english.saigonbiz.com\/vn\/#organization"},"articleSection":["Pr Newswire"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/","url":"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/","name":"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency - Biz and Live in Saigon","isPartOf":{"@id":"https:\/\/english.saigonbiz.com\/vn\/#website"},"datePublished":"2024-07-22T12:03:38+00:00","dateModified":"2024-07-22T12:03:38+00:00","breadcrumb":{"@id":"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/english.saigonbiz.com\/vn\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/english.saigonbiz.com\/vn\/"},{"@type":"ListItem","position":2,"name":"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency"}]},{"@type":"WebSite","@id":"https:\/\/english.saigonbiz.com\/vn\/#website","url":"https:\/\/english.saigonbiz.com\/vn\/","name":"Biz and Live in Saigon","description":"","publisher":{"@id":"https:\/\/english.saigonbiz.com\/vn\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/english.saigonbiz.com\/vn\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/english.saigonbiz.com\/vn\/#organization","name":"SaigonBiz Media","url":"https:\/\/english.saigonbiz.com\/vn\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/logo\/image\/","url":"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2026\/03\/cropped-c2adea16-1c71-4315-8801-803a8d237e2a_removalai_preview.png","contentUrl":"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2026\/03\/cropped-c2adea16-1c71-4315-8801-803a8d237e2a_removalai_preview.png","width":512,"height":512,"caption":"SaigonBiz Media"},"image":{"@id":"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/SaigonbizGroup"]},{"@type":"Person","@id":"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/267b348e6cf32a66aab33637c2d399a6","name":"admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/image\/","url":"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2026\/03\/c2adea16-1c71-4315-8801-803a8d237e2a_removalai_preview-2_uwp_avatar_thumb.png","contentUrl":"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2026\/03\/c2adea16-1c71-4315-8801-803a8d237e2a_removalai_preview-2_uwp_avatar_thumb.png","caption":"admin"},"sameAs":["https:\/\/english.saigonbiz.com\/vn"],"url":"https:\/\/english.saigonbiz.com\/vn\/profile\/admin\/"}]}},"_links":{"self":[{"href":"https:\/\/english.saigonbiz.com\/vn\/wp-json\/wp\/v2\/posts\/57472","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/english.saigonbiz.com\/vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/english.saigonbiz.com\/vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/english.saigonbiz.com\/vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/english.saigonbiz.com\/vn\/wp-json\/wp\/v2\/comments?post=57472"}],"version-history":[{"count":0,"href":"https:\/\/english.saigonbiz.com\/vn\/wp-json\/wp\/v2\/posts\/57472\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/english.saigonbiz.com\/vn\/wp-json\/wp\/v2\/media\/79226"}],"wp:attachment":[{"href":"https:\/\/english.saigonbiz.com\/vn\/wp-json\/wp\/v2\/media?parent=57472"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/english.saigonbiz.com\/vn\/wp-json\/wp\/v2\/categories?post=57472"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/english.saigonbiz.com\/vn\/wp-json\/wp\/v2\/tags?post=57472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}