{"id":58617,"date":"2024-08-23T12:04:17","date_gmt":"2024-08-23T12:04:17","guid":{"rendered":"https:\/\/english.saigonbiz.com.vn\/2024\/08\/23\/corina-intrauterine-drug-eluting-system-approved-in-china-as-a-novel-treatment-for-patients-with-moderate-to-severe-intrauterine-adhesions-iua\/"},"modified":"2024-08-23T12:04:17","modified_gmt":"2024-08-23T12:04:17","slug":"corina-intrauterine-drug-eluting-system-approved-in-china-as-a-novel-treatment-for-patients-with-moderate-to-severe-intrauterine-adhesions-iua","status":"publish","type":"post","link":"https:\/\/english.saigonbiz.com\/vn\/corina-intrauterine-drug-eluting-system-approved-in-china-as-a-novel-treatment-for-patients-with-moderate-to-severe-intrauterine-adhesions-iua\/","title":{"rendered":"Corina Intrauterine Drug-Eluting System approved in China as a novel treatment for patients with moderate-to-severe intrauterine adhesions (IUA)"},"content":{"rendered":"
\n

The World’s First-in-Class <\/b>Intrauterine Drug-Eluting <\/b>System <\/b><\/p>\n

SHANGHAI<\/span><\/span>, Aug. 23, 2024<\/span><\/span> \/PRNewswire\/ — Corina Intrauterine Drug-Eluting <\/b>System<\/b>\u00a0(“Corina”),<\/b> developed by Yipurun (Shanghai<\/span>) Biotechnology Co., Ltd. (“YPR”), has received approval in China<\/span> (G.X.Z.Z. 20243181461) for use in patients with moderate-to-severe intrauterine adhesions (IUA)\u00a0who undergo transcervical resection of adhesions (TCRA). The approval for this indication is based on a randomized controlled clinical trial that demonstrated Corina’s superior\u00a0efficacy compared to the standard-of-care. Corina is a first-in-class treatment focused on promoting female reproductive health through the prevention of intrauterine re-adhesion risk post TCRA, and the improvement of endometrial growth.<\/p>\n

Intrauterine adhesions (IUA) are the formation of scar tissues in the endometrial cavity as a result of damages to the endometrial basal layer of the uterus, which leads to the partial or complete occlusion of the cervical canal and uterine cavity. Clinically, IUA can cause a range of symptoms such as reduced menstrual flow, amenorrhea, infertility and recurrent miscarriage\u00a0\u2013 thereby\u00a0posing a serious threat to the reproductive health of women of childbearing age. Currently, the incidence rate of IUA in China<\/span> remains high, and continues to grow due to an increased number of intrauterine interventions. Research in this field show the incidence rate of IUA in China<\/span> to be as high as 25% in women who have had prior abortion\u00a0or curettage procedures [1]<\/sup>\u00a0\u2014 this has become a key driver of reduced menstrual flow and secondary infertility\u00a0in women of childbearing age.\u00a0As a standard surgical procedure to treat\u00a0IUA, TCRA separates the adherent tissues and restores the anatomical shape of the uterine cavity. Surveys show\u00a01.6 to 1.8 million patients in China<\/span> undergo\u00a0TCRA every year, but the recurrence rate of IUA after surgery is still as high as 62.5%\u00a0[2]<\/sup>; and the pregnancy success rate of patients after TCRA surgery is only 22.5%~33.3%\u00a0[3-4]<\/sup>.\u00a0Over the years, a variety of adjuvant therapies, such as uterine cavity isolation barriers and hormonal treatments, have emerged with limited efficacy.<\/p>\n

Corina is an innovative drug-device-combination therapy made from non-degradable, medical grade material, carrying the active ingredient estradiol. Designed to conform to the shape of the female uterus, Corina acts as a physical barrier upon insertion,\u00a0and enables targeted delivery of estradiol to the endometrium. With YPR’s proprietary controlled-release technology, Corina can continuously release\u00a0the active substance up to 60 days post procedure\u00a0to promote endometrium growth.<\/p>\n

\n

\"Corina<\/a>
Corina acts as a physical barrier upon insertion, and enables targeted delivery of estradiol to the endometrium<\/span><\/p>\n<\/p><\/div>\n

The registration study results of Corina\u00a0have demonstrated statistically significant and clinically meaningful reduction in intrauterine adhesion at 60 days post procedure, compared to standard-of-care therapy. Corina has also shown meaningful improvement in endometrial thickness from baseline at 60 days post procedure, compared to standard-of-care therapy.<\/p>\n

\n

\"Evaluating<\/a>
Evaluating effectiveness data from clinical trials<\/span><\/p>\n<\/p><\/div>\n

A<\/b>bout Puyi Biotech<\/b><\/p>\n

Located in the Zhangjiang Hi-Tech Park in Shanghai,\u00a0Yipurun (Shanghai<\/span>) Biotechnology Co., Ltd. (‘YPR’) is a wholly-owned subsidiary of Puyi (Shanghai<\/span>) Biotechnology Co., Ltd. (“Puyi Biotech”\u00a0or “Group”). Leveraging its knowhow in biomedical material science\u00a0and its proprietary drug-eluting technology, Puyi Biotech and YPR have developed an innovative R&D pipeline of high-end implantable therapeutics. Since its founding in 2012, Puyi Biotech has focused on providing innovative solutions to address unmet clinical needs\u00a0across\u00a0women’s health, ENT (ear, nose and throat), and medical aesthetics\u00a0categories. The Group has a number of renowned institutions as investors including Goldman Sachs Alternatives, Legend Capital and Northern Light VC.<\/p>\n

\n\n\n\n\n\n\n\n
\n

References<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[1] \u00a02015 Chinese expert consensus on the clinical diagnosis and treatment of intrauterine adhesions<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[2] Yu\u00a0D\u00a0,\u00a0Wong\u00a0YM\u00a0,\u00a0Cheong\u00a0Y\u00a0,et al.\u00a0Asherman syndrome: one century later[J].\u00a0Fertil Steril,\u00a02008,89(4):759\u2013779.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[3] Yu\u00a0D\u00a0,\u00a0Li\u00a0TC\u00a0,\u00a0Xia\u00a0E\u00a0,et al.\u00a0Factors affecting reproductive outcome of hysteroscopic adhesiolysis for Asherman’s syndrome[J].\u00a0Fertil Steril,\u00a02008,89(3):715\u2013722.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[4] Roy\u00a0KK\u00a0,\u00a0Baruah\u00a0J\u00a0,\u00a0Sharma\u00a0JB\u00a0,et al.\u00a0Reproductive outcome following hysteroscopic adhesiolysis in patients with infertility due to Asherman’s syndrome[J].\u00a0Arch Gynecol Obstet,\u00a02010,281(2):355\u2013361.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

Contact Us
Address: Room 2206, No. 396, Lishizhen Road, Pudong New Area, Shanghai, China<\/span>
Company Contact Tel: +86-21-50805520, Merchants Phone: +86-21-58556388
Website: en.puyibio.com
Email: service@puyibio.com<\/a><\/p>\n

\u00a0<\/p>\n

<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The World’s First-in-Class Intrauterine Drug-Eluting System SHANGHAI, Aug. 23, 2024 \/PRNewswire\/ — Corina Intrauterine Drug-Eluting System\u00a0(“Corina”), developed by Yipurun (Shanghai) Biotechnology Co., Ltd. (“YPR”), has received approval in China (G.X.Z.Z. 20243181461) for use in patients with moderate-to-severe intrauterine adhesions (IUA)\u00a0who undergo transcervical resection of adhesions (TCRA). The approval for this indication is based on a […]\n","protected":false},"author":1,"featured_media":79226,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-58617","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\nCorina Intrauterine Drug-Eluting System approved in China as a novel treatment for patients with moderate-to-severe intrauterine adhesions (IUA) - Biz and Live in Saigon<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/english.saigonbiz.com\/vn\/corina-intrauterine-drug-eluting-system-approved-in-china-as-a-novel-treatment-for-patients-with-moderate-to-severe-intrauterine-adhesions-iua\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Corina Intrauterine Drug-Eluting System approved in China as a novel treatment for patients with moderate-to-severe intrauterine adhesions (IUA)\" \/>\n<meta property=\"og:description\" content=\"The World’s First-in-Class Intrauterine Drug-Eluting System SHANGHAI, Aug. 23, 2024 \/PRNewswire\/ — Corina Intrauterine Drug-Eluting System\" \/>\n<meta property=\"og:url\" content=\"https:\/\/english.saigonbiz.com\/vn\/corina-intrauterine-drug-eluting-system-approved-in-china-as-a-novel-treatment-for-patients-with-moderate-to-severe-intrauterine-adhesions-iua\/\" \/>\n<meta property=\"og:site_name\" content=\"Biz and Live in Saigon\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SaigonbizGroup\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-23T12:04:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mma.prnasia.com\/media2\/2488376\/Corina_acts_a_physical_barrier_insertion_enables_targeted_delivery_estradiol.jpg?p=medium600\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/corina-intrauterine-drug-eluting-system-approved-in-china-as-a-novel-treatment-for-patients-with-moderate-to-severe-intrauterine-adhesions-iua\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/corina-intrauterine-drug-eluting-system-approved-in-china-as-a-novel-treatment-for-patients-with-moderate-to-severe-intrauterine-adhesions-iua\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/267b348e6cf32a66aab33637c2d399a6\"},\"headline\":\"Corina Intrauterine Drug-Eluting System approved in China as a novel treatment for patients with moderate-to-severe intrauterine adhesions (IUA)\",\"datePublished\":\"2024-08-23T12:04:17+00:00\",\"dateModified\":\"2024-08-23T12:04:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/corina-intrauterine-drug-eluting-system-approved-in-china-as-a-novel-treatment-for-patients-with-moderate-to-severe-intrauterine-adhesions-iua\/\"},\"wordCount\":684,\"publisher\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#organization\"},\"articleSection\":[\"Pr Newswire\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/corina-intrauterine-drug-eluting-system-approved-in-china-as-a-novel-treatment-for-patients-with-moderate-to-severe-intrauterine-adhesions-iua\/\",\"url\":\"https:\/\/english.saigonbiz.com\/vn\/corina-intrauterine-drug-eluting-system-approved-in-china-as-a-novel-treatment-for-patients-with-moderate-to-severe-intrauterine-adhesions-iua\/\",\"name\":\"Corina Intrauterine Drug-Eluting System approved in China as a novel treatment for patients with moderate-to-severe intrauterine adhesions (IUA) - 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