{"id":59026,"date":"2024-09-04T00:04:39","date_gmt":"2024-09-04T00:04:39","guid":{"rendered":"https:\/\/english.saigonbiz.com.vn\/2024\/09\/04\/ipax-1-study-of-tlx101-investigational-glioblastoma-therapy-published-in-neuro-oncology-advances\/"},"modified":"2024-09-04T00:04:39","modified_gmt":"2024-09-04T00:04:39","slug":"ipax-1-study-of-tlx101-investigational-glioblastoma-therapy-published-in-neuro-oncology-advances","status":"publish","type":"post","link":"https:\/\/english.saigonbiz.com\/vn\/ipax-1-study-of-tlx101-investigational-glioblastoma-therapy-published-in-neuro-oncology-advances\/","title":{"rendered":"IPAX-1 Study of TLX101 Investigational Glioblastoma Therapy Published in Neuro-Oncology Advances"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/1920208\/Telix_Main_Logo_Logo.jpg?p=medium600\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"xn-location\">MELBOURNE, Australia<\/span>, <span class=\"xn-chron\">Sept. 4, 2024<\/span> \/PRNewswire\/ &#8212; Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces that the Company&#8217;s IPAX-1 Phase I study has been published in <i>Neuro-Oncology Advances, <\/i>confirming the safety and tolerability profile, and early efficacy\u00a0of TLX101 therapy, in combination with external beam radiation therapy (EBRT) in recurrent glioblastoma (GBM), the most common and aggressive form of primary brain cancer.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>TLX101 (4-L-[ <sup>131<\/sup>I] iodo-phenylalanine, or <sup>131<\/sup>I-IPA) is a systemically administered targeted radiation therapy that targets L-type amino acid transporter 1 (LAT1), which is typically over-expressed in GBM.<\/p>\n<p>In the first peer-reviewed publication of the IPAX-1 study, Professor <span class=\"xn-person\">Josef Pichler<\/span> and colleagues report that single or fractionated doses of TLX101 plus EBRT were associated with acceptable tolerability and specific tumour-targeting in patients with recurrent GBM. Authors explain that the study delivered encouraging preliminary efficacy data, demonstrating a median overall survival (OS) of 13 months from the initiation of treatment, or 23 months from initial diagnosis. Given that GBM has a median survival from initial diagnosis of 12-15 months, authors conclude that findings from the IPAX-1 study &#8220;support further investigation into the use of TLX101 plus EBRT, including its potential as a first line treatment&#8221;.<\/p>\n<p><b>Key findings of the IPAX-1 study, outlined in the paper, include:<\/b><\/p>\n<ul type=\"disc\">\n<li>All dosing regimens were well tolerated.<\/li>\n<li>Organ-absorbed radiation doses in the red bone marrow (0.38 Gy) and kidney (1.28 Gy) confirmed no radiation-based toxicity.<\/li>\n<li>Stable disease with MRI<sup>[1]<\/sup> assessment was observed in 4 of 9 patients at 3 months post-treatment (3-month follow-up, 1 patient did not reach protocol-mandated end of study), yielding a response rate of 44.4%.<\/li>\n<li>At the 3-month follow-up, 6 patients demonstrated metabolic stable disease with\u00a0<sup>18<\/sup>F-FET PET imaging.<\/li>\n<li>Median progression-free survival was 4.3 months (95% confidence interval, 3.3\u20134.5), while median OS was 13 months from the initiation of treatment (95% confidence interval, 7.1\u201327), or 23 months from initial diagnosis.<\/li>\n<\/ul>\n<p>Metabolic tumour responses were determined using Telix&#8217;s investigational PET<sup>[2]<\/sup> agent for glioma imaging, TLX101-CDx (Pixclara\u00ae<sup>[3]<\/sup>,\u00a0<sup>18<\/sup>F-floretyrosine or\u00a0<sup>18<\/sup>F-FET).<\/p>\n<p>Professor <span class=\"xn-person\">Josef Pichler<\/span>, Kepler University Hospital, <span class=\"xn-location\">Austria<\/span>, Principal Investigator in the IPAX-1, IPAX-2 and IPAX-Linz studies, and lead author, commented, &#8220;A significant unmet need exists for well-tolerated and efficacious treatments for patients with glioblastoma. The results from this Phase I study demonstrate the favourable safety and tolerability profile and preliminary efficacy of TLX101 in combination with second-line EBRT, in patients with recurrent glioblastoma. Following treatment with TLX101 plus EBRT, stable disease was observed in 44% of patients at 3 months post-treatment and median progression-free survival was 4.3 months, with no confirmed radiation toxicity. The overall survival improvement trend seen in this patient population clearly warrants further investigation into the use of TLX101 plus EBRT, including its potential as a first-line treatment. These studies are now well advanced.&#8221;<\/p>\n<p>Dr David N Cade, Chief Medical Officer at Telix said, &#8220;We believe that TLX101 has significant potential to improve outcomes for patients living with glioblastoma \u2013 a disease in urgent need of new treatment options. In the front-line setting, the standard of care has not advanced materially in almost two decades, and in recurrent disease, no standard treatment exists. We are encouraged by these data, which show that TLX101, in combination with EBRT, is well tolerated at the doses tested, with preliminary clinical evidence demonstrating an anti-tumour effect and disease stabilisation &#8211; outcomes that are very important for this advanced patient population. Telix is pleased to be at the forefront of developing a new therapy for glioblastoma, and we welcome the excellent work conducted by Professor Pichler and his colleagues to progress this.&#8221;<\/p>\n<p>The IPAX-2 and IPAX-Linz studies in the front-line and recurrent settings continue to progress well in combination with standard of care, and using Telix&#8217;s Pixclara\u00ae<sup>3<\/sup> investigational PET agent as companion diagnostic. Data from IPAX-1, together with these studies, will inform the design of Telix&#8217;s future registration-enabling trial for TLX101.<\/p>\n<p>The Neuro-Oncology Advances publication is available online at: <a href=\"https:\/\/academic.oup.com\/noa\/article\/6\/1\/vdae130\/7723438\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/academic.oup.com\/noa\/article\/6\/1\/vdae130\/7723438<\/a><\/p>\n<p><b>About TLX101<\/b><\/p>\n<p>TLX101 is Telix&#8217;s LAT1-targeting investigational therapy for patients with brain cancer. TLX101 therapy utilises a small molecule approach due to the need to cross the blood brain barrier, the normal protective barrier that prevents many potential drug candidates entering the brain. TLX101 has received orphan drug designation in the U.S. and <span class=\"xn-location\">Europe<\/span> for the treatment of glioma.<\/p>\n<p><b>About the IPAX series of studies<\/b><\/p>\n<ul type=\"disc\">\n<li><b>IPAX-1<\/b>\u00a0was a multicenter, open-label, single-arm Phase I study to evaluate TLX101 plus EBRT in patients with recurrent GBM. The primary objective of the IPAX-1 study was to evaluate the safety and tolerability profile of intravenous TLX101 administered concurrently with second line EBRT. Secondary objectives were to determine optimal dosing, biodistribution and radiation absorption into the tumour, as well as assess preliminary efficacy through clinical and imaging-based assessment of tumour response. ClinicalTrials.gov ID: <a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT03849105\" target=\"_blank\" rel=\"nofollow noopener\">NCT03849105<\/a>.<\/li>\n<li><b>IPAX-2<\/b>\u00a0is a Phase I study of TLX101 in combination with post-surgical standard of care treatment in patients with newly diagnosed GBM. Active, dosing patients. ClinicalTrials.gov ID: <a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT05450744\" target=\"_blank\" rel=\"nofollow noopener\">NCT05450744<\/a>.<\/li>\n<li><b>IPAX-Linz<\/b>\u00a0is a Phase II investigator-initiated trial of TLX101 in combination with EBRT in patients with recurrent high-grade gliomas (HGG), including GBM. Active, dosing patients.<\/li>\n<\/ul>\n<p><b>About <\/b><b>Telix Pharmaceuticals Limited <\/b><\/p>\n<p>Telix is a biopharmaceutical company focused on the development and commercialisation of therapeutic and diagnostic radiopharmaceuticals and associated medical devices. Telix is headquartered in <span class=\"xn-location\">Melbourne, Australia<\/span>, with international operations in <span class=\"xn-location\">the United States<\/span>, <span class=\"xn-location\">Europe<\/span> (<span class=\"xn-location\">Belgium<\/span> and <span class=\"xn-location\">Switzerland<\/span>), and <span class=\"xn-location\">Japan<\/span>. Telix is developing a portfolio of clinical and commercial stage products that aims to address significant unmet medical needs in oncology and rare diseases. Telix is listed on the Australian Securities Exchange (ASX: TLX).<\/p>\n<p>Telix&#8217;s lead imaging product, gallium-68 (<sup>68<\/sup>Ga) gozetotide injection (also known as <sup>68<\/sup>Ga PSMA-11 and marketed under the brand name Illuccix\u00ae), has been approved by the U.S. Food and Drug Administration (FDA)<sup>[4]<\/sup>, by the Australian Therapeutic Goods Administration (TGA)\u00a0<sup>[5]<\/sup>, and by Health Canada<sup>[6]<\/sup>. No other Telix product has received a marketing authorisation in any jurisdiction.<\/p>\n<p>Visit <a href=\"http:\/\/www.telixpharma.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.telixpharma.com<\/a> for further information about Telix, including details of the latest share price, announcements made to the ASX, investor and analyst presentations, news releases, event details and other publications that may be of interest. You can also follow Telix on <a href=\"https:\/\/x.com\/TelixPharma\" target=\"_blank\" rel=\"nofollow noopener\">X<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.linkedin.com\/company\/telixpharma\/\" target=\"_blank\" rel=\"nofollow noopener\">LinkedIn<\/a>.<\/p>\n<p><b>Telix Investor Relations<\/b><\/p>\n<p>Ms. Kyahn Williamson<br \/>Telix Pharmaceuticals Limited<br \/>SVP Investor Relations and Corporate Communications<br \/>Email: <a href=\"mailto:kyahn.williamson@telixpharma.com\" target=\"_blank\" rel=\"nofollow noopener\">kyahn.williamson@telixpharma.com<\/a><\/p>\n<p>Legal Notices<\/p>\n<p><i>You should read this announcement together with our risk factors, as disclosed in our most recently filed reports with the Australian Securities Exchange (ASX) or on our website. <\/i><\/p>\n<p><i>The information contained in this announcement is not intended to be an offer for subscription, invitation or recommendation with respect to securities of Telix Pharmaceuticals Limited (Telix) in any jurisdiction, including <span class=\"xn-location\">the United States<\/span>. The information and opinions contained in this announcement are subject to change without notification. \u00a0To the maximum extent permitted by law, Telix disclaims any obligation or undertaking to update or revise any information or opinions contained in this announcement, including any forward-looking statements (as referred to below), whether as a result of new information, future developments, a change in expectations or assumptions, or otherwise. No representation or warranty, express or implied, is made in relation to the accuracy or completeness of the information contained or opinions expressed in the course of this announcement. <\/i><\/p>\n<p><i>This announcement may contain forward-looking statements that relate to anticipated future events, financial performance, plans, strategies or business developments. Forward-looking statements can generally be identified by the use of words such as &#8220;may&#8221;, &#8220;expect&#8221;, &#8220;intend&#8221;, &#8220;plan&#8221;, &#8220;estimate&#8221;, &#8220;anticipate&#8221;, &#8220;believe&#8221;, &#8220;outlook&#8221;, &#8220;forecast&#8221; and &#8220;guidance&#8221;, or the negative of these words or other similar terms or expressions. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to differ materially from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking statements. Forward-looking statements are based on Telix&#8217;s good-faith assumptions as to the financial, market, regulatory and other risks and considerations that exist and affect Telix&#8217;s business and operations in the future and there can be no assurance that any of the assumptions will prove to be correct. In the context of Telix&#8217;s business, forward-looking statements may include, but are not limited to, statements about: the initiation, timing, progress and results of Telix&#8217;s preclinical and clinical trials, and Telix&#8217;s research and development programs; Telix&#8217;s ability to advance product candidates into, enrol and successfully complete, clinical studies, including multi-national clinical trials; the timing or likelihood of regulatory filings and approvals for Telix&#8217;s product candidates, manufacturing activities and product marketing activities; Telix&#8217;s sales, marketing and distribution and manufacturing capabilities and strategies; the commercialisation of Telix&#8217;s product candidates, if or when they have been approved; Telix&#8217;s ability to obtain an adequate supply of raw materials at reasonable costs for its products and product candidates; estimates of Telix&#8217;s expenses, future revenues and capital requirements; Telix&#8217;s financial performance; developments relating to Telix&#8217;s competitors and industry; and the pricing and reimbursement of Telix&#8217;s product candidates, if and after they have been approved. Telix&#8217;s actual results, performance or achievements may be materially different from those which may be expressed or implied by such statements, and the differences may be adverse. Accordingly, you should not place undue reliance on these forward-looking statements. <\/i><\/p>\n<p><i>\u00a92024 Telix Pharmaceuticals Limited. The Telix Pharmaceuticals\u00ae, Illuccix\u00ae and Pixclara\u00ae<sup>3<\/sup> names and logos are trademarks of Telix Pharmaceuticals Limited and its affiliates \u2013 all rights reserved.<\/i><\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] Magnetic resonance imaging.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2]\u00a0Positron emission tomography.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3]\u00a0Brand name subject to final regulatory approval.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[4]\u00a0Telix ASX disclosure 20 December 2021.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[5]\u00a0Telix ASX disclosure 2 November 2021.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[6]\u00a0Telix ASX disclosure 14 October 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>MELBOURNE, Australia, Sept. 4, 2024 \/PRNewswire\/ &#8212; Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces that the Company&#8217;s IPAX-1 Phase I study has been published in Neuro-Oncology Advances, confirming the safety and tolerability profile, and early efficacy\u00a0of TLX101 therapy, in combination with external beam radiation therapy (EBRT) in recurrent glioblastoma (GBM), the most [&#8230;]\n","protected":false},"author":1,"featured_media":79226,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-59026","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.6 (Yoast SEO v21.6) - 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