{"id":59191,"date":"2024-09-09T00:05:10","date_gmt":"2024-09-09T00:05:10","guid":{"rendered":"https:\/\/english.saigonbiz.com.vn\/2024\/09\/09\/hutchmed-highlights-clinical-data-to-be-presented-at-esmo-congress-2024-and-the-2024-world-conference-of-lung-cancer\/"},"modified":"2024-09-09T00:05:10","modified_gmt":"2024-09-09T00:05:10","slug":"hutchmed-highlights-clinical-data-to-be-presented-at-esmo-congress-2024-and-the-2024-world-conference-of-lung-cancer","status":"publish","type":"post","link":"https:\/\/english.saigonbiz.com\/vn\/hutchmed-highlights-clinical-data-to-be-presented-at-esmo-congress-2024-and-the-2024-world-conference-of-lung-cancer\/","title":{"rendered":"HUTCHMED Highlights Clinical Data to be Presented at ESMO Congress 2024 and the 2024 World Conference of Lung Cancer"},"content":{"rendered":"
\n

HONG KONG and SHANGHAI and FLORHAM PARK, N.J., Sept. 09, 2024 (GLOBE NEWSWIRE) — HUTCHMED (China) Limited (\u201cHUTCHMED<\/a>\u201d) (Nasdaq\/AIM:HCM; HKEX:13) today announces that new and updated data from several studies of compounds discovered by HUTCHMED will be presented at the 2024 World Conference on Lung Cancer (\u201cWCLC24\u201d) in San Diego, USA, and the European Society for Medical Oncology (\u201cESMO\u201d) Congress 2024, taking place in Barcelona, Spain.<\/p>\n

Results from the FLOWERS study, a prospective, two-arm, randomized, multicenter Phase II clinical trial of osimertinib with or without savolitinib as first-line treatment in EGFRm, MET-aberrant advanced non-small cell lung cancer (\u201cNSCLC\u201d) patients, will be presented at WCLC24. As of May 28, 2024, the median follow-up was 8.2 months. Patients treated with osimertinib plus savolitinib (Cohort 2, N=21) showed deeper and more durable response over osimertinib monotherapy (Cohort 1, N=23) along the study follow-up. The confirmed objective response rate (ORR) in Cohort 1 and Cohort 2 were 60.9% and 90.5%, respectively, with disease control rate (DCR) of 87% and 95.2%, respectively. Immature progression-free survival (\u201cPFS\u201d) data also showed a positive trend in favor of the combination therapy, with median PFS of 9.3 months and 19.6 months in the cohort 1 and cohort 2 with maturity of 34.8% and 23.8%, respectively. Safety profiles of osimertinib monotherapy and osimertinib plus savolitinib were as expected, tolerable and manageable.<\/p>\n\n\n\n\n\n\n\n
Abstract title<\/strong><\/td>\nPresenter \/ Lead author<\/strong><\/td>\nPresentation details<\/strong><\/td>\n<\/tr>\n
WCLC24 – INVESTIGATOR-INITIATED STUDIES <\/strong><\/td>\n<\/tr>\n
Osimertinib with or without savolitinib as 1L in de novo MET aberrant, EGFRm advanced NSCLC (CTONG 2008): A Phase II trial<\/strong><\/td>\nJinji Yang,
Guangdong Lung Cancer Institute, Guangdong Provincial People\u2019s Hospital, Southern Medical University, Guangzhou, China<\/td>\n		PL04.10<\/a>
Plenary Session
PL04 Presidential Symposium 2,
Plenary Hall
Monday, September 9, 2024 at
8:30 AM PDT<\/td>\n<\/tr>\n
Study of Surufatinib Combined with Low Dose Topotecan in Second or Third-Line Multiple Distant Organ Metastatic ES-SCLC<\/strong><\/td>\nYingying Du, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Hesheng Qian, Fuyang Cancer Hospital, Fuyang, China<\/td>\nEP.13A.04A<\/a>
ePoster
Saturday, September 7, 2024<\/td>\n<\/tr>\n
Surufatinib Plus Docetaxel in Patients with Relapsed Advanced Driver-Negative Non-Squamous NSCLC: A Phase Ib\/II Study <\/strong><\/td>\nQitao Yu, Wei Jiang,
Guangxi Medical University Cancer Hospital, Nanning, China<\/p>\n<\/td>\n		P3.12C.08<\/a>
Poster
Monday, September 9, 2024 at
8:30 AM PDT<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n<\/table>\n

Further analysis of fruquintinib\u2019s FRESCO-2 study in metastatic colorectal cancer and FRUTIGA study in gastric cancer, a biomarker study of savolitinib in gastric cancer as well as investigator-initiated studies of fruquintinib and surufatinib will be presented at the ESMO Congress 2024. Details of the presentations are as follows:<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Abstract title<\/strong><\/td>\nPresenter \/ Lead author<\/strong><\/td>\nPresentation details<\/strong><\/td>\n<\/tr>\n
ESMO 2024 – SPONSORED STUDIES<\/strong><\/td>\n<\/tr>\n
Efficacy and safety of\u00a0fruquintinib\u00a0in patients with refractory metastatic colorectal cancer with and without liver metastasis: A subgroup analysis of the phase 3 FRESCO-2 trial<\/strong><\/td>\nRocio Garcia-Carbonero,
Hospital Universitario 12 de Octubre, lmas12, UCM, Madrid, Spain<\/td>\n		520P
Poster Session \u2013 Colorectal cancer
Monday, 16 September 2024<\/td>\n<\/tr>\n
Efficacy and safety of fruquintinib in refractory metastatic colorectal cancer: A FRESCO-2 subgroup analysis by age<\/strong><\/td>\nMaria Elena Elez Fernandez,
Vall d’Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain<\/td>\n		526P
Poster Session \u2013 Colorectal cancer
Monday, 16 September 2024<\/td>\n<\/tr>\n
Efficacy of fruquintinib plus paclitaxel (F+PTX) in patients (pts) with prior immunotherapy (prior-IO): subgroup analysis from\u00a0FRUTIGA\u00a0study<\/strong><\/td>\nLin Shen,
Peking University Cancer Hospital & Institute, Beijing, China<\/td>\n		1410P
Poster Session \u2013 Oesophagogastric cancer
Monday, 16 September 2024<\/td>\n<\/tr>\n
Impact of subsequent anti-tumor therapies in patients (pts) with advanced gastric or gastroesophageal junction (G\/GEJ) adenocarcinoma receiving fruquintinib (F) plus paclitaxel (PTX) or placebo plus PTX in\u00a0FRUTIGA\u00a0study<\/strong><\/td>\nRuihua Xu,
Sun Yat-sen University Cancer Center, Guangzhou, China<\/td>\n		1434P
Poster Session \u2013 Oesophagogastric cancer
Monday, 16 September 2024<\/td>\n<\/tr>\n
Association between Fruquintinib-induced Hypertension and Clinical Outcomes from FRUTIGA, a Phase 3 Study of Fruquintinib plus Paclitaxel in Previously Treated Advanced Gastric or Gastroesophageal Junction (G\/GEJ) Adenocarcinoma<\/strong><\/td>\nShukui Qin,
Chinese People’s Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing, China<\/td>\n		1443P
Poster Session \u2013 Oesophagogastric cancer
Monday, 16 September 2024<\/td>\n<\/tr>\n
Analysis of MET gene alterations in cfDNA samples from a phase II study of\u00a0savolitinib\u00a0in patients (pts) with MET-amplified gastroesophageal junction adenocarcinomas or gastric cancer (GEJ\/GC)<\/strong><\/td>\nZhi Peng,
Peking University Cancer Hospital & Institute, Beijing, China<\/td>\n		1461P
Poster Session \u2013 Oesophagogastric cancer
Monday, 16 September 2024<\/td>\n<\/tr>\n
\u00a0<\/td>\n<\/tr>\n
ESMO 2024 – INVESTIGATOR-INITIATED STUDIES <\/strong><\/td>\n<\/tr>\n
A phase II clinical study of\u00a0fruquintinib\u00a0(Fru) combined with toripalimab (Tor) and short-course radiotherapy (SCRT) as neoadjuvant therapy for locally advanced rectal cancer (LARC)<\/strong><\/td>\nZhiping Li, Ye Chen,
West China Hospital of Sichuan University, Chengdu, China<\/td>\n		570P
Poster Session \u2013 Colorectal cancer
Monday, 16 September 2024<\/td>\n<\/tr>\n
Stereotactic ablative radiotherapy combined with fruquintinib and tislelizumab in metastatic colorectal cancer: Updated findings from a single-arm, prospective phase II trial (RIFLE)<\/strong><\/td>\nZhen Zhang, Yajie Chen,
Fudan University Shanghai Cancer Center, Shanghai, China<\/td>\n		537P\u00a0
Poster Session \u2013 Colorectal cancer
Monday, 16 September 2024<\/td>\n<\/tr>\n
Fruquintinib\u00a0combined with sintilimab and chemotherapy as the first-line treatment in advanced na\u00efve EGFR- and ALK-negative non-squamous non-small cell lung cancer (nsq-NSCLC): Updated results<\/strong><\/p>\n<\/td>\nYongqian Shu, Pei Ma,
Jiangsu Province Hospital\/The First Affiliated Hospital of Nanjing Medical University, Nanjing, China<\/td>\n		1329P\u00a0
Poster Session \u2013 NSCLC, metastatic
Saturday, 14 September 2024<\/td>\n<\/tr>\n
Fruquintinib in combination with sintilimab and CAPEOX as first-line treatment for advanced G\/GEJ cancer: A phase 1b\/2 clinical trial (FUNCTION)<\/strong><\/p>\n<\/td>\nXiaobing Chen, Beibei Chen,
Henan Cancer Hospital\/ Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China<\/td>\n		1475TiP
Poster Session \u2013 Oesophagogastric cancer
Monday, 16 September 2024<\/td>\n<\/tr>\n
Fruquintinib combined with nab-paclitaxel and gemcitabine (AG) as the first-line treatment for pancreatic ductal adenocarcinoma (PDAC) with liver metastases: An open-label, single-arm, single-center phase II clinical study<\/strong><\/td>\nXianjun Yu, Miaoyan Wei,
Fudan University Shanghai Cancer Center, Shanghai, China<\/td>\n		1529P\u00a0
Poster Session \u2013 Pancreatic cancer
Monday, 16 September 2024<\/td>\n<\/tr>\n
A phase II study of\u00a0Fruquintinib\u00a0in the 1L or 2L treatment of unresectable metastatic soft tissue sarcoma<\/strong><\/td>\nZhiguo Luo, Xiaowei Zhang,
Fudan University Shanghai Cancer Center, Shanghai, China<\/td>\n		1743P
Poster Session \u2013 Sarcoma
Saturday, 14 September 2024<\/td>\n<\/tr>\n
Surufatinib\u00a0combined with anti-PD-1\/PD-L1 antibody in the second line or monotherapy in third line treatment of advanced hepatocellular carcinoma: A single-arm, open-label, multi-center phase II study<\/strong><\/td>\nFuxiang Zhou,
Zhongnan Hospital, Wuhan University, Wuhan, China<\/td>\n		974P
Poster Session \u2013 Hepatocellular carcinoma (HCC)
Monday, 16 September 2024<\/td>\n<\/tr>\n
Updated results of\u00a0Surufatinib\u00a0plus transarterial embolization versus\u00a0surufatinib\u00a0monotherapy in neuroendocrine tumor with liver metastasis: a prospective, randomized, controlled trial<\/strong><\/td>\nDan Cao,
West China Hospital, Sichuan University, Chengdu, China<\/td>\n		1155P
Poster Session \u2013 Neuroendocrine tumours
Monday, 16 September 2024<\/td>\n<\/tr>\n
Surufatinib\u00a0plus toripalimab combined with pemetrexed (A), and platinum (P) in patients (pts) with advanced non-squamous non-small cell lung cancer (nsq-NSCLC): Updated results of a single-center, phase II trial<\/strong><\/td>\nLi Zhang, Wenfeng Fang,
Sun Yat-Sen University Cancer Center, Guangzhou, China<\/td>\n		1345P
Poster Session \u2013 NSCLC, metastatic
Saturday, 14 September 2024<\/td>\n<\/tr>\n
Surufatinib\u00a0combined with gemcitabine in soft tissue sarcoma (STS) patients failed with anthracyclines chemotherapy or monotherapy post-anlotinib progression: a multi-center, phase II trial<\/strong><\/td>\nXiaohui Niu, Yuhong Zhou,
Zhongshan Hospital, Fudan University, Shanghai, China<\/td>\n		1740P
Poster Session \u2013 Sarcoma
Saturday, 14 September 2024<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n<\/table>\n

About HUTCHMED<\/strong><\/p>\n

HUTCHMED (Nasdaq\/AIM:\u200b<\/strong>HCM; HKEX:\u200b<\/strong>13) is an innovative, commercial-stage, biopharmaceutical company. It is committed to the discovery, global development and commercialization of targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. It has approximately 5,000 personnel across all its companies, at the center of which is a team of about 1,800 in oncology\/immunology. Since inception, HUTCHMED has focused on bringing cancer drug candidates from in-house discovery to patients around the world, with its first three medicines marketed in China, the first of which is also marketed in the US and Europe. For more information, please visit: www.hutch-med.com<\/a> or follow us on LinkedIn<\/a>.<\/p>\n

Forward-Looking Statements <\/em><\/strong><\/p>\n

This press release contains forward-looking statements within the meaning of the \u201csafe harbor\u201d provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements reflect HUTCHMED\u2019s current expectations regarding future events, including but not limited to its expectations regarding the therapeutic potential of fruquintinib, savolitinib and surufatinib, the further clinical development for fruquintinib, savolitinib and surufatinib, its expectations as to whether any studies on fruquintinib, savolitinib and surufatinib, would meet their primary or secondary endpoints, and its expectations as to the timing of the completion and the release of results from such studies. Such risks and uncertainties include, among other things, assumptions regarding enrollment rates and the timing and availability of subjects meeting a study\u2019s inclusion and exclusion criteria; changes to clinical protocols or regulatory requirements; unexpected adverse events or safety issues; the ability of fruquintinib, savolitinib and surufatinib, including as combination therapies, to meet the primary or secondary endpoint of a study, to obtain regulatory approval in different jurisdictions and to gain commercial acceptance after obtaining regulatory approval; the potential markets of fruquintinib, savolitinib and surufatinib for a targeted indication, and the sufficiency of funding. In addition, as certain studies rely on the use of CAPEOX, docetaxel, gemcitabine, nab-paclitaxel, paclitaxel, pemetrexed, platinum, sintilimab, topotecan, tislelizumab or toripalimab as combination therapeutics, such risks and uncertainties include assumptions regarding their safety, efficacy, supply and continued regulatory approval. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. For further discussion of these and other risks, see HUTCHMED\u2019s filings with the U.S. Securities and Exchange Commission, The Stock Exchange of Hong Kong Limited and on AIM. HUTCHMED undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise.<\/em><\/p>\n

Medical Information<\/em><\/strong><\/p>\n

This press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.<\/em><\/p>\n

CONTACTS<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
Investor Enquiries<\/strong><\/td>\n+852\u00a02121\u00a08200 \/ ir@hutch-med.com<\/a><\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
Media Enquiries<\/strong><\/td>\n\u00a0<\/td>\n<\/tr>\n
Ben Atwell \/ Alex Shaw, FTI\u00a0Consulting<\/td>\n+44\u00a020\u00a03727\u00a01030\u00a0\/ +44\u00a07771\u00a0913\u00a0902\u00a0(Mobile)\u00a0\/ +44\u00a07779\u00a0545\u00a0055\u00a0(Mobile)\u00a0\/ HUTCHMED@fticonsulting.com<\/a><\/td>\n<\/tr>\n
Zhou Yi, Brunswick<\/td>\n+852\u00a09783\u00a06894\u00a0(Mobile)\u00a0\/ HUTCHMED@brunswickgroup.com<\/a><\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
Nominated Advisor<\/strong><\/td>\n\u00a0<\/td>\n<\/tr>\n
Atholl Tweedie \/ Freddy Crossley \/
Rupert Dearden, Panmure Liberum<\/td>\n		+44\u00a0(20)\u00a07886\u00a02500<\/td>\n<\/tr>\n<\/table>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

HONG KONG and SHANGHAI and FLORHAM PARK, N.J., Sept. 09, 2024 (GLOBE NEWSWIRE) — HUTCHMED (China) Limited (\u201cHUTCHMED\u201d) (Nasdaq\/AIM:HCM; HKEX:13) today announces that new and updated data from several studies of compounds discovered by HUTCHMED will be presented at the 2024 World Conference on Lung Cancer (\u201cWCLC24\u201d) in San Diego, USA, and the European Society […]\n","protected":false},"author":1,"featured_media":59192,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-59191","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\nHUTCHMED Highlights Clinical Data to be Presented at ESMO Congress 2024 and the 2024 World Conference of Lung Cancer - Biz and Live in Saigon<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/english.saigonbiz.com\/vn\/hutchmed-highlights-clinical-data-to-be-presented-at-esmo-congress-2024-and-the-2024-world-conference-of-lung-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HUTCHMED Highlights Clinical Data to be Presented at ESMO Congress 2024 and the 2024 World Conference of Lung Cancer\" \/>\n<meta property=\"og:description\" content=\"HONG KONG and SHANGHAI and FLORHAM PARK, N.J., Sept. 09, 2024 (GLOBE NEWSWIRE) — HUTCHMED (China) Limited (\u201cHUTCHMED\u201d) (Nasdaq\/AIM:HCM; HKEX\" \/>\n<meta property=\"og:url\" content=\"https:\/\/english.saigonbiz.com\/vn\/hutchmed-highlights-clinical-data-to-be-presented-at-esmo-congress-2024-and-the-2024-world-conference-of-lung-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Biz and Live in Saigon\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SaigonbizGroup\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-09T00:05:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2024\/09\/HUTCHMED-China-Limited.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1\" \/>\n\t<meta property=\"og:image:height\" content=\"1\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/hutchmed-highlights-clinical-data-to-be-presented-at-esmo-congress-2024-and-the-2024-world-conference-of-lung-cancer\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/hutchmed-highlights-clinical-data-to-be-presented-at-esmo-congress-2024-and-the-2024-world-conference-of-lung-cancer\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/267b348e6cf32a66aab33637c2d399a6\"},\"headline\":\"HUTCHMED Highlights Clinical Data to be Presented at ESMO Congress 2024 and the 2024 World Conference of Lung Cancer\",\"datePublished\":\"2024-09-09T00:05:10+00:00\",\"dateModified\":\"2024-09-09T00:05:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/hutchmed-highlights-clinical-data-to-be-presented-at-esmo-congress-2024-and-the-2024-world-conference-of-lung-cancer\/\"},\"wordCount\":1582,\"publisher\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#organization\"},\"articleSection\":[\"Pr Newswire\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/hutchmed-highlights-clinical-data-to-be-presented-at-esmo-congress-2024-and-the-2024-world-conference-of-lung-cancer\/\",\"url\":\"https:\/\/english.saigonbiz.com\/vn\/hutchmed-highlights-clinical-data-to-be-presented-at-esmo-congress-2024-and-the-2024-world-conference-of-lung-cancer\/\",\"name\":\"HUTCHMED Highlights Clinical Data to be Presented at ESMO Congress 2024 and the 2024 World Conference of Lung Cancer - 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