{"id":60186,"date":"2024-10-04T00:04:35","date_gmt":"2024-10-04T00:04:35","guid":{"rendered":"https:\/\/english.saigonbiz.com.vn\/2024\/10\/04\/first-patient-dosed-in-phase-ii-ca-nine-trial-of-tlx250-cdx-for-detection-of-recurrent-kidney-cancer-after-surgery\/"},"modified":"2024-10-04T00:04:35","modified_gmt":"2024-10-04T00:04:35","slug":"first-patient-dosed-in-phase-ii-ca-nine-trial-of-tlx250-cdx-for-detection-of-recurrent-kidney-cancer-after-surgery","status":"publish","type":"post","link":"https:\/\/english.saigonbiz.com\/vn\/first-patient-dosed-in-phase-ii-ca-nine-trial-of-tlx250-cdx-for-detection-of-recurrent-kidney-cancer-after-surgery\/","title":{"rendered":"First Patient Dosed in Phase II ‘CA-NINE’ Trial of TLX250-CDx for Detection of Recurrent Kidney Cancer After Surgery"},"content":{"rendered":"
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MELBOURNE, Australia<\/span><\/span>, Oct. 4, 2024<\/span><\/span> \/PRNewswire\/ — Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces that the first patient has been dosed in a Phase II trial exploring the clinical utility of Telix’s first-in-class investigational PET[1]<\/sup> agent, TLX250-CDx (89<\/sup>Zr-girentuximab) in recurrent clear cell renal cell carcinoma (ccRCC) after surgery.<\/p>\n

\n<\/p><\/div>\n

‘CA-NINE’[2]<\/sup> \u2013 led by Professor Brian Shuch<\/span> at University of California, Los Angeles<\/span> (UCLA<\/span>) \u2013 is a Phase II prospective, single-centre trial comparing the diagnostic performance of TLX250-CDx\u00a0PET\/CT[3]<\/sup> to conventional imaging (contrast-enhanced CT alone) in 91 patients with intermediate-to-high risk ccRCC post-surgery. The investigator-initiated trial is designed to identify ccRCC where it has recurred, including metastatic disease, and is one of multiple trials either underway or planned, which may inform future label expansion for TLX250-CDx.<\/p>\n

Professor Brian Shuch<\/span>, MD, Director of the Kidney Cancer Program and the Alvin & Carrie Meinhardt Endowed Chair in Kidney Cancer Research at UCLA Institute of Urologic Oncology, and Principal Investigator on the CA-NINE trial, said, “Telix’s ZIRCON trial demonstrated the accuracy of TLX250-CDx at diagnosing localised ccRCC. However, we know that many patients die of metastatic disease, where the cancer has spread. There are plenty of data showing that metastatic ccRCC also expresses the carbonic anhydrase IX (CAIX) biomarker, which demonstrates potential use beyond localised ccRCC. We are on the cusp of a revolution in how we detect and manage\u00a0advanced kidney cancer before and after surgery, and I’m excited to work with Telix to hopefully bring this technology to patients should it receive regulatory approval.”<\/p>\n

Associate Professor Jeremie Calais<\/span>, MD, Director of the Theranostics Program of the Ahmanson Translational Theranostics Division of the Department of Molecular and Medical Pharmacology at UCLA School of Medicine, and an investigator on the CA-NINE trial, added, “With TLX250-CDx it is exciting that we can now characterise indeterminate renal masses with greater confidence. However, this only scratches the surface of the clinical potential of this investigational agent.\u00a0With conventional imaging, we are very limited in our ability to stage patients, and we are hopeful that this investigational agent will improve patient outcomes by shedding light on sites of recurrent ccRCC outside of the kidney.”<\/p>\n

Dr David N. Cade<\/span>, Chief Medical Officer at Telix continued, “We are pleased that a first patient has been imaged in the CA-NINE trial, which supports potential label expansion for TLX250-CDx into recurrent, metastatic disease. We would like to thank Professor Shuch and Associate Professor Calais at UCLA<\/span> for their commitment to addressing unmet medical need in kidney cancer, as well as the patients who will contribute to this important trial.”<\/p>\n

About TLX250-CDx <\/b><\/p>\n

TLX250-CDx (Zircaix\u00ae[4]<\/sup> 89<\/sup>Zr-girentuximab) is an investigational PET agent\u00a0that is under development to characterise indeterminate renal masses as ccRCC or non-ccRCC in a non-invasive manner. Telix’s pivotal Phase III ZIRCON trial (ClinicalTrials.gov ID: NCT03849118<\/a>) evaluating TLX250-CDx in 300\u00a0patients, of which 284 were evaluable, met all primary and secondary endpoints, including showing 86% sensitivity and 87% specificity and a 93% positive-predictive value for ccRCC across three independent readers[5]<\/sup>. We believe this demonstrated the ability of TLX250-CDx to reliably detect the clear cell phenotype and provide an accurate, non-invasive method for diagnosing ccRCC. Confidence intervals exceeded expectations in all three readers, showing evidence of high accuracy and consistency of interpretation.<\/p>\n

As part of Telix’s commitment to access to medicine, the Company continues to run\u00a0an expanded access program (EAP) in the U.S.[6]<\/sup>, named patient programs (NPPs) in Europe<\/span>, and a special access scheme (SAS) in Australia<\/span> to allow continued access to TLX250-CDx outside of a clinical trial to patients for whom there are no comparable or satisfactory alternate options.<\/p>\n

Telix’s Policy on Offering Compassionate Use to Investigational Medicines can be downloaded at the following link<\/a>.<\/p>\n

About <\/b>Telix Pharmaceuticals Limited <\/b><\/p>\n

Telix is a biopharmaceutical company focused on the development and commercialisation of therapeutic and diagnostic radiopharmaceuticals and associated medical devices. Telix is headquartered in Melbourne, Australia<\/span>, with international operations in the United States<\/span>, Europe<\/span> (Belgium<\/span> and Switzerland<\/span>), and Japan<\/span>. Telix is developing a portfolio of clinical and commercial stage products that aims to address significant unmet medical needs in oncology and rare diseases. Telix is listed on the Australian Securities Exchange (ASX: TLX).<\/p>\n

Telix’s lead imaging product, gallium-68 (68<\/sup>Ga) gozetotide injection (also known as 68<\/sup>Ga PSMA-11 and marketed under the brand name Illuccix\u00ae), has been approved by the U.S. Food and Drug Administration (FDA)[7]<\/sup>, by the Australian Therapeutic Goods Administration (TGA)\u00a0[8]<\/sup>, and by Health Canada[9]<\/sup><\/sup>. No other Telix product has received a marketing authorisation in any jurisdiction.<\/p>\n

Visit www.telixpharma.com<\/a> for further information about Telix, including details of the latest share price, announcements made to the ASX, investor and analyst presentations, news releases, event details and other publications that may be of interest. You can also follow Telix on X<\/a>\u00a0and\u00a0LinkedIn<\/a>.<\/p>\n

Telix Investor Relations<\/b><\/p>\n

Ms. Kyahn Williamson
Telix Pharmaceuticals Limited
SVP Investor Relations and Corporate Communications
Email: kyahn.williamson@telixpharma.com<\/a><\/p>\n

Legal Notices<\/p>\n

You should read this announcement together with our risk factors, as disclosed in our most recently filed reports with the Australian Securities Exchange (ASX) or on our website. <\/i><\/p>\n

The information contained in this announcement is not intended to be an offer for subscription, invitation or recommendation with respect to securities of Telix Pharmaceuticals Limited (Telix) in any jurisdiction, including the United States<\/span>. The information and opinions contained in this announcement are subject to change without notification. \u00a0To the maximum extent permitted by law, Telix disclaims any obligation or undertaking to update or revise any information or opinions contained in this announcement, including any forward-looking statements (as referred to below), whether as a result of new information, future developments, a change in expectations or assumptions, or otherwise. No representation or warranty, express or implied, is made in relation to the accuracy or completeness of the information contained or opinions expressed in the course of this announcement. <\/i><\/p>\n

This announcement may contain forward-looking statements that relate to anticipated future events, financial performance, plans, strategies or business developments. Forward-looking statements can generally be identified by the use of words such as “may”, “expect”, “intend”, “plan”, “estimate”, “anticipate”, “believe”, “outlook”, “forecast” and “guidance”, or the negative of these words or other similar terms or expressions. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to differ materially from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking statements. Forward-looking statements are based on Telix’s good-faith assumptions as to the financial, market, regulatory and other risks and considerations that exist and affect Telix’s business and operations in the future and there can be no assurance that any of the assumptions will prove to be correct. In the context of Telix’s business, forward-looking statements may include, but are not limited to, statements about: the initiation, timing, progress and results of Telix’s preclinical and clinical trials, and Telix’s research and development programs; Telix’s ability to advance product candidates into, enrol and successfully complete, clinical studies, including multi-national clinical trials; the timing or likelihood of regulatory filings and approvals for Telix’s product candidates, manufacturing activities and product marketing activities; Telix’s sales, marketing and distribution and manufacturing capabilities and strategies; the commercialisation of Telix’s product candidates, if or when they have been approved; Telix’s ability to obtain an adequate supply of raw materials at reasonable costs for its products and product candidates; estimates of Telix’s expenses, future revenues and capital requirements; Telix’s financial performance; developments relating to Telix’s competitors and industry; and the pricing and reimbursement of Telix’s product candidates, if and after they have been approved. Telix’s actual results, performance or achievements may be materially different from those which may be expressed or implied by such statements, and the differences may be adverse. Accordingly, you should not place undue reliance on these forward-looking statements. <\/i><\/p>\n

\u00a92024 Telix Pharmaceuticals Limited. The Telix Pharmaceuticals\u00ae and Illuccix\u00ae and Zircaix\u00ae[4]<\/sup> names and logos are trademarks of Telix Pharmaceuticals Limited and its affiliates \u2013 all rights reserved.<\/i><\/p>\n

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[1] <\/sup>Positron emission tomography.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[2]\u00a0<\/sup>ClinicalTrials.gov ID:\u00a0NCT06447103<\/a>.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[3]\u00a0<\/sup>Computed tomography.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[4]\u00a0<\/sup>Brand name subject to final regulatory approval.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[5]\u00a0<\/sup>Shuch et al. Lancet Oncology.<\/i> 2024.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[6]\u00a0<\/sup>ClinicalTrials.gov ID: NCT06090331<\/a>.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[7]\u00a0<\/sup>Telix ASX disclosure 20 December 2021.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[8]<\/sup>\u00a0Telix ASX disclosure 2 November 2021.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[9]<\/sup>\u00a0Telix ASX disclosure 14 October 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

MELBOURNE, Australia, Oct. 4, 2024 \/PRNewswire\/ — Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces that the first patient has been dosed in a Phase II trial exploring the clinical utility of Telix’s first-in-class investigational PET[1] agent, TLX250-CDx (89Zr-girentuximab) in recurrent clear cell renal cell carcinoma (ccRCC) after surgery. ‘CA-NINE’[2] \u2013 led by […]\n","protected":false},"author":1,"featured_media":79226,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-60186","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\nFirst Patient Dosed in Phase II 'CA-NINE' Trial of TLX250-CDx for Detection of Recurrent Kidney Cancer After Surgery - Biz and Live in Saigon<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/english.saigonbiz.com\/vn\/first-patient-dosed-in-phase-ii-ca-nine-trial-of-tlx250-cdx-for-detection-of-recurrent-kidney-cancer-after-surgery\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First Patient Dosed in Phase II 'CA-NINE' Trial of TLX250-CDx for Detection of Recurrent Kidney Cancer After Surgery\" \/>\n<meta property=\"og:description\" content=\"MELBOURNE, Australia, Oct. 4, 2024 \/PRNewswire\/ — Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces that the first pa\" \/>\n<meta property=\"og:url\" content=\"https:\/\/english.saigonbiz.com\/vn\/first-patient-dosed-in-phase-ii-ca-nine-trial-of-tlx250-cdx-for-detection-of-recurrent-kidney-cancer-after-surgery\/\" \/>\n<meta property=\"og:site_name\" content=\"Biz and Live in Saigon\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SaigonbizGroup\" \/>\n<meta property=\"article:published_time\" content=\"2024-10-04T00:04:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mma.prnasia.com\/media2\/1920208\/Telix_Main_Logo_Logo.jpg?p=medium600\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/first-patient-dosed-in-phase-ii-ca-nine-trial-of-tlx250-cdx-for-detection-of-recurrent-kidney-cancer-after-surgery\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/first-patient-dosed-in-phase-ii-ca-nine-trial-of-tlx250-cdx-for-detection-of-recurrent-kidney-cancer-after-surgery\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/267b348e6cf32a66aab33637c2d399a6\"},\"headline\":\"First Patient Dosed in Phase II ‘CA-NINE’ Trial of TLX250-CDx for Detection of Recurrent Kidney Cancer After Surgery\",\"datePublished\":\"2024-10-04T00:04:35+00:00\",\"dateModified\":\"2024-10-04T00:04:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/first-patient-dosed-in-phase-ii-ca-nine-trial-of-tlx250-cdx-for-detection-of-recurrent-kidney-cancer-after-surgery\/\"},\"wordCount\":1404,\"publisher\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#organization\"},\"articleSection\":[\"Pr Newswire\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/first-patient-dosed-in-phase-ii-ca-nine-trial-of-tlx250-cdx-for-detection-of-recurrent-kidney-cancer-after-surgery\/\",\"url\":\"https:\/\/english.saigonbiz.com\/vn\/first-patient-dosed-in-phase-ii-ca-nine-trial-of-tlx250-cdx-for-detection-of-recurrent-kidney-cancer-after-surgery\/\",\"name\":\"First Patient Dosed in Phase II 'CA-NINE' Trial of TLX250-CDx for Detection of Recurrent Kidney Cancer After Surgery - 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