{"id":63888,"date":"2025-01-23T00:01:30","date_gmt":"2025-01-23T00:01:30","guid":{"rendered":"https:\/\/english.saigonbiz.com.vn\/2025\/01\/23\/data-published-today-in-the-new-england-journal-of-medicine-demonstrates-anthos-therapeutics-novel-factor-xi-inhibitor-abelacimab-150mg-reduced-major-or-clinically-relevant-non-major-bleedi\/"},"modified":"2025-01-23T00:01:30","modified_gmt":"2025-01-23T00:01:30","slug":"data-published-today-in-the-new-england-journal-of-medicine-demonstrates-anthos-therapeutics-novel-factor-xi-inhibitor-abelacimab-150mg-reduced-major-or-clinically-relevant-non-major-bleedi","status":"publish","type":"post","link":"https:\/\/english.saigonbiz.com\/vn\/data-published-today-in-the-new-england-journal-of-medicine-demonstrates-anthos-therapeutics-novel-factor-xi-inhibitor-abelacimab-150mg-reduced-major-or-clinically-relevant-non-major-bleedi\/","title":{"rendered":"Data Published Today in the New England Journal of Medicine Demonstrates Anthos Therapeutics\u2019 novel Factor XI inhibitor, Abelacimab 150mg, Reduced Major or Clinically Relevant Non-Major Bleeding by 62% Compared to Rivaroxaban (Xarelto) in Patients with Atrial Fibrillation"},"content":{"rendered":"<div>\n<p align=\"center\"><em>Secondary endpoints also showed a highly significant 67% reduction in major bleeding and an 89% reduction in gastrointestinal (GI) bleeding<\/em><\/p>\n<p align=\"center\"><em>The company\u2019s AZALEA-TIMI 71 study is the longest head-to-head study of a Factor XI inhibitor vs. a direct oral anticoagulant (DOAC)<\/em><\/p>\n<p>CAMBRIDGE, Mass., Jan.  22, 2025  (GLOBE NEWSWIRE) &#8212; Anthos Therapeutics, Inc., a transformative, clinical-stage biopharmaceutical company developing innovative therapies for the treatment of cardiovascular metabolic diseases, founded by Blackstone Life Sciences, announced today the publication of the results of the landmark AZALEA-TIMI 71 study in the January 23 issue of the <em>New England Journal of Medicine<\/em> (<em>NEJM<\/em>).<\/p>\n<p>Originally <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=m__J3N0CTdTrOAELeInf7LJr_9yiR7EM7svWrrrCzC_jakRj_IFsY_ZR56QHGT3eTtIiaRujJnu3L3u10M7zcy9IbQ0I0PGLvmKNS5-9M8Ihf92eNnDbVnxokT1kSPRUrprI4ugnEX21CluAGTpcrtAau8OmXYCRRNPAY4ocTO_X7_nXnWgueAMrGubi5Ca7TBruCRdWMxH3ut8odm-nZw==\" rel=\"nofollow\" target=\"_blank\" title=\"presented\">presented<\/a> at a late-breaking session of the 2023 American Heart Association (AHA) meeting, the <em>NEJM<\/em> publication provides more complete clinical details of the study, which demonstrated an unprecedented reduction in bleeding events in patients taking abelacimab versus a standard of care direct-oral anticoagulant (DOAC) across all primary and secondary endpoints in patients with atrial fibrillation.<\/p>\n<p>Atrial fibrillation, also known as AFib, is an irregular heartbeat, or arrhythmia, which can increase the risk of stroke by five times and cause other heart-related complications.<sup>1<\/sup> Affecting 60 million people worldwide,<sup>2<\/sup> the prevalence of AFib is expected to increase by 60% by 2050 due to an aging population and rising cardiometabolic risk factors.<sup>3<\/sup> In addition, the Centers for Disease Control and Prevention (CDC) estimates that more than 12 million Americans will have AFib by 2030.<sup>4<\/sup><\/p>\n<p>Today, 40% to 60% of patients with AFib are either not prescribed anticoagulants or are undertreated.<sup>5<\/sup> In a physician survey, the foremost barrier to patients taking oral anticoagulants was the risk of bleeding.<sup>6<\/sup> This underuse of anticoagulants for stroke prevention has been cited as one of the greatest public health issues facing cardiovascular patients.<sup>7<\/sup><\/p>\n<p>\u201cMany doctors are put in the unfortunate position of having to weigh the risk of stroke against the risk of bleeding for their patients with AFib,\u201d said Christian T. Ruff, MD, MPH, director of General Cardiology at Brigham and Women\u2019s Hospital, associate professor of Medicine at Harvard Medical School, senior investigator in the TIMI Study Group, and principal investigator of the AZALEA-TIMI 71 trial. \u201cThis study reinforces the promise of abelacimab as a potentially safer alternative to current anticoagulants to address the risk of bleeding.\u201d<\/p>\n<p><strong>Study<\/strong> <strong>Highlights<\/strong><sup>8<\/sup><\/p>\n<ul type=\"disc\">\n<li>Median 99% inhibition of Factor XI sustained over 2 years with abelacimab 150 mg dosed once monthly<\/li>\n<li>62% reduction in major or clinically relevant non-major bleeding with abelacimab 150 mg compared with rivaroxaban 20 mg in patients with AFib who are at moderate-to-high risk of stroke (P&lt;0.001, HR 0.38, 95% Cl 0.24\u20130.60)<\/li>\n<li>67% reduction in major bleeding alone with abelacimab 150 mg vs rivaroxaban 20 mg (P=0.001, HR 0.33, 95% CI 0.16-0.66)<\/li>\n<li>89% reduction in gastrointestinal (GI) bleeding<\/li>\n<\/ul>\n<p>With a median follow up of 21 months, the <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=FbOVEHU9Ove0_9tzQE9-ixx5c6jK2hj2tU1gXOTuaLzn64Y9TJMfHfSakivq8cwvZ2Bu5iEw7K2IY3MWXPFyUNAIY3sDlLT8qQuFAbItUO8=\" rel=\"nofollow\" target=\"_blank\" title=\"AZALEA-TIMI 71\">AZALEA-TIMI 71<\/a> Phase 2 study is the longest head-to-head study to date of a Factor XI inhibitor, and provides evidence of a highly significant reduction in bleeding versus a DOAC. In September 2023, the study was stopped early by the Independent Data Monitoring Committee (IDMC) due to an overwhelming, greater-than-anticipated reduction in major and clinically relevant non-major bleeding with abelacimab and a benefit\/risk profile favoring abelacimab.<\/p>\n<p>Additional <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=gxM8x9A5qpAw7bBzeA2KmeqaApuvNuOla9Df6bVN5goOtpyZhbYVWl3mQhbTOz90HbP3KqECwQ_l0dHJtwEDjZX47WdoVfzGpkOFdARKtqU-AJs7SiS1_bur15FA_UHfFg2bL5Dj43p2dmY-rjgQnA==\" rel=\"nofollow\" target=\"_blank\" title=\"data\">data<\/a> from the AZALEA-TIMI 71 study comparing abelacimab to rivaroxaban, which was presented last September at the European Society of Cardiology meeting, demonstrated low levels of bleeding during surgical procedures, also referred to as periprocedural bleeding, despite patients being fully anticoagulated with abelacimab. Additional <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=gxM8x9A5qpAw7bBzeA2KmTIOmXjV7BJpPXtzEyX3cWp_Yx93iuFSPQIUugEOvUSYliU73perG3fjq6mKAQRpIctyrEWUR3q38l9-oV5-GzWTvN62H5vguGh2J2oAF2bGApR8N26OvdWRTVv6NWlMOQ==\" rel=\"nofollow\" target=\"_blank\" title=\"data\">data<\/a> from the study presented at the American Heart Association\u2019s Scientific Sessions last November showed that even among patients on antiplatelet therapy, abelacimab reduced bleeding as compared with rivaroxaban.<\/p>\n<p>\u201cBuilding on the overwhelmingly positive data from the AZALEA study, data on the safety of abelacimab in patients undergoing surgical procedures as well as data in patients taking antiplatelet therapy further reinforce the fundamental premise of the promise of Factor XI inhibition \u2013 the potential to prevent thrombotic events without affecting normal hemostasis,\u201d said Dan Bloomfield, MD, Chief Medical Officer of Anthos Therapeutics. \u201cEven when the risk of bleeding is highest, during surgery or invasive procedures or when using antiplatelet therapy, patients treated with abelacimab have a very low rate of bleeding, despite near complete inhibition of Factor XI. The growing body of safety data on abelacimab elevates its promise for patients and, if approved, its potential to be a very attractive therapeutic option for those seeking a safer, more convenient anticoagulant.\u201d<\/p>\n<p>In September 2022, the Food and Drug Administration (FDA) granted abelacimab Fast Track status for the prevention of stroke and systemic embolism in patients with AFib, recognizing the unmet need and the potential benefits of abelacimab. Anthos Therapeutics\u2019 LILAC-TIMI 76 <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=XFfuxxsJIFuvifsv0MP4b6AgdreUKza1lC8omY6GfH0r1eXG3SmaWbmmeEVan1tiIRU6q37IxMmlAXFbPebjJYErE3AMEUayVYDUkcfdOvbWiIbjDxIecDxdUWiMeiG_kmji98mX6zUehz6Z2Vms2g==\" rel=\"nofollow\" target=\"_blank\" title=\"study\">study<\/a> launched in January 2023 and was designed to determine whether abelacimab can reduce the rate of stroke in AFib patients more effectively and safely compared to placebo. Study completion is anticipated for the second half of 2026.<\/p>\n<p>Media contact: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=52eNH_VBiKNRZW1iX21DsWOtwpYaFG-1ktsewiCqyHuhpkJBn7LxrycUlGhK__6SORWfVNk6EQyczVk7I-QLUN_QsCmgzN4ajg3wrknqHEPLtJMj5pYgbmdgunTgUzAx\" rel=\"nofollow\" target=\"_blank\" title=\"media@anthostherapeutics.com\">media@anthostherapeutics.com<\/a><\/p>\n<p><strong>About Anthos Therapeutics<\/strong><br \/>Founded by <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=SwjwBzp0ufABgDW7G21FhVMoAaZMyRZWxdZN7i03jSHPQ_U5xK9J2GLLz0d1cACe70D9dCZ4-MTSmM-ohfGy4RLwQB3GZ-7iz7io3vNCdmy6ivGEeTwmn2f3SwrCGLo73SjVuMhx7ekKnt4392LjUA==\" rel=\"nofollow\" target=\"_blank\" title=\"Blackstone Life Sciences\">Blackstone Life Sciences<\/a> (BXLS) in 2019, Anthos Therapeutics is a transformative, clinical-stage biopharmaceutical company with the exclusive global rights from Novartis Pharma AG to develop, manufacture and commercialize abelacimab. For more information, visit the Company\u2019s <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=jswguML5E_vXYmhd_IO2AeMR6utUz7KWDQDrW8B3MXN7ncUfMJdUb5JZadaJtmKeN0vUsexc_Ejrv3LzC5oupw==\" rel=\"nofollow\" target=\"_blank\" title=\"website\">website<\/a> or follow us on <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=9ztAQPdywStrY12ba_Kxz_nbVC0aXSTxEY-Q_WPfJAsxE5nLMIgWstdywYF0ZzQfMH0c99P6yLKcJAg0kyJuQA==\" rel=\"nofollow\" target=\"_blank\" title=\"X\">X<\/a> and <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=4rZaU4lZI-WVXjOVs2vM2Hk5j2caoPh2Q6C8Y171piVPcLEX_4AEI4JFp2oXY1-MwUoqbkeEa13hwEH7NV957IA0s-fu7ZqzyTn7jH3RXNLq81ZuNfc__NryagdWY-m2N4Fl45NnFchIIjsVHglMyA==\" rel=\"nofollow\" target=\"_blank\" title=\"LinkedIn\">LinkedIn<\/a>.<\/p>\n<p><strong>About Abelacimab<\/strong><br \/>Abelacimab is a novel, investigational, highly selective, fully human monoclonal antibody that binds tightly to Factor XI to block its activation and prevent the generation of the activated form (Factor XIa). This mimics natural Factor XI deficiency, which is associated with protection from thromboembolic disease.<\/p>\n<p>Abelacimab received a Fast Track Designation from the FDA in July 2022 for the treatment of thrombosis associated with cancer. In September 2022, abelacimab was also granted a Fast Track Designation for the prevention of stroke and systemic embolism in patients with atrial fibrillation.<\/p>\n<p><strong>Forward-Looking Statements<\/strong><br \/>This press release contains \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties, including statements regarding our research and development activities, the potential benefits of abelacimab and our goals to further develop and commercialize abelacimab. All statements, other than statements of historical facts, contained in this press release, including statements regarding the company\u2019s strategy, future operations, future financial position, prospects, plans and objectives of management, are forward-looking statements. The words \u201canticipate,\u201d \u201cbecome,\u201d \u201cbelieve,\u201d \u201ccontinue,\u201d \u201ccould,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201cshould,\u201d \u201ctarget,\u201d \u201cwill,\u201d \u201cwould\u201d and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements are based on management\u2019s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in, or implied by, such forward-looking statements. In addition, the forward-looking statements included in this press release represent the company\u2019s views as of the date hereof and should not be relied upon as representing the company\u2019s views as of any date subsequent to the date hereof. The company anticipates that subsequent events and developments will cause the company\u2019s views to change. However, while the company may elect to update these forward-looking statements at some point in the future, the company specifically disclaims any obligation to do so.<\/p>\n<p><strong>References<\/strong><br \/><sup>1<\/sup>\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Zl68OjZ5tU3wKFaJNTGNAVXv9QVrtxPcq3Mczi58x6Cst7g9IWYwbc_4rs3Y5S5ToWauwDLySt2DyiSXzLiwAvm84JXGHbb-8jlGw3luh8b2c1TCKDPGZU1NFYHmMfzBNBSOk3yYwzbqAmnhvH061gLwLreWI_QMkhCVjpf-Fi2j5RJtgYO1IZSlHFrHiZg0\" rel=\"nofollow\" target=\"_blank\" title=\"Sanders GD et al. Comparative Effectiveness Reviews. Oct. 2018\">Sanders GD et al. Comparative Effectiveness Reviews. Oct. 2018<\/a><br \/><sup>2<\/sup> <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=hcZlfU2e_dr9LtOiVwyd1z7tRMEtTDS8F3XMIzV6JdXRm0RSRVFjT9hMn9n18pK7rCtULkYGzrcsO5aQreAZMrrQNDeoU8PtZHFcwouMYjx7XxAPICPNcET6HL1DEdPZwcUp5T-JtV9X4iA82AnOZ88ynSJmE8nwsiveueSWz8ABc2_YUvAE3hPKcRGc0tJe\" rel=\"nofollow\" target=\"_blank\" title=\"Patel SM, Ruff CT. Curr Cardiol Rep. Jul. 2024\">Patel SM, Ruff CT. Curr Cardiol Rep. Jul. 2024<\/a><br \/><sup>3<\/sup> <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Bf7zQESaUCeS4m9u5TUkHaqvEzrKh5shu064K0bCJT5xojZVW7MLZ9rnIH_DLUQ9ZnAGO4ZUjAEQfcbwtAOB1PjiJ_GqqLLoAGaj2HA6YwDaxn3pbuGNfba3J4nxR_HN4Jp_JizUgl_-8UhGLst0f4lFhITE7RGcT-4AXjVsMwU=\" rel=\"nofollow\" target=\"_blank\" title=\"Rahman F et al. Nat Rev Cardiol. Aug. 2014\">Rahman F et al. Nat Rev Cardiol. Aug. 2014<\/a><br \/><sup>4<\/sup> <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=qmM4jfSOlstoCiatr8RF7cvFXLcIgxV2UF4AI7TfwedrqwhGQNrTnn_eZuvFAgvK8MihaOJIu1rpr-m7x7SuzxNurTOw04RqRx5ozxTaomvxYiO5snv1dn9HP3jN3542FzCi3wrc8u8v2tniNHzbBQ==\" rel=\"nofollow\" target=\"_blank\" title=\"\">Colilla S et al.\u00a0Am J Cardiol<em>.<\/em>\u00a0Jul. 2013<\/a><br \/><sup>5 <\/sup><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=yEvHsgN_Q0ONqIHeKOb1_Ck1Y8HSYSDHbKO7axCN5lRNeCTyjiUZ6j7CTH3d7J9Bggi5cHUKQWqEPpDcykJ2m_FK3Q4aE48TswBYxR73Qe2qKw8-q4kSWj4jrItvdB9dtwRr-cLzodIyhBBiSXDYgGiczxf7Wz9f7bP74KOrVwA=\" rel=\"nofollow\" target=\"_blank\" title=\"Hsu J et al JAMA Cardiol. Apr. 2016\">Hsu J et al JAMA Cardiol. Apr. 2016<\/a><br \/><sup>6<\/sup> <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=qKl_u4McuztDBCkq6zgTVo3ZTP2HI2lWwvkiJIbzNy97SK7hezQB03ZIB1CT8MTVIsw23Q7Q9NGeGM5KrOy7VMiCfDtlfzYquE2eurDuBsEJyr1b7sgN89CwMi8llAbxPgB_jm3DXoCXfFbv6oNHiw==\" rel=\"nofollow\" target=\"_blank\" title=\"Yao C et al. PEC Innov. Jun. 2022\">Yao C et al. PEC Innov. Jun. 2022<\/a><br \/><sup>7<\/sup> <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=zwraIHIEfhahAHK0nK8exNfaYcWzkdw-E-IEM39yWFOQ60yAYNTlOxVGhC41UrZkG3ahCjRXkt_afukyR-yLx3ISMl9sDVR2erVJziMH7NIdHvq7oKxTbwtquQEiXCsAeR2Ir1QP3d64Vnoj6fQ2QHDLyOZT5nYrff9jjsVUL_noSipB3FxUWNZxIZX_hMOYfvcN8XbK_Kvg3h3yQ05Jgg==\" rel=\"nofollow\" target=\"_blank\" title=\"Pokorney SD et al. Am Heart J. Apr. 2019\">Pokorney SD et al. Am Heart J. Apr. 2019<\/a><br \/><sup>8 <\/sup>Ruff C et al. N Engl J Med. Jan. 2025<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/ZDg2NDI0Y2ItNjVhNC00OTk1LTgwZTEtOWM4MzUyMTE2ZDYwLTEzMDc3NTQ=\/tiny\/Anthos-Therapeutics.png\" referrerpolicy=\"no-referrer-when-downgrade\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Secondary endpoints also showed a highly significant 67% reduction in major bleeding and an 89% reduction in gastrointestinal (GI) bleeding The company\u2019s AZALEA-TIMI 71 study is the longest head-to-head study of a Factor XI inhibitor vs. a direct oral anticoagulant (DOAC) CAMBRIDGE, Mass., Jan. 22, 2025 (GLOBE NEWSWIRE) &#8212; Anthos Therapeutics, Inc., a transformative, clinical-stage [&#8230;]\n","protected":false},"author":1,"featured_media":63889,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-63888","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.6 (Yoast SEO v21.6) - 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