{"id":70221,"date":"2025-07-23T12:08:55","date_gmt":"2025-07-23T12:08:55","guid":{"rendered":"https:\/\/english.saigonbiz.com.vn\/2025\/07\/23\/jupiter-neurosciences-highlights-critical-advancement-of-jotrol-over-traditional-resveratrol-with-breakthrough-bioavailability-and-cns-targeted-science\/"},"modified":"2025-07-23T12:08:55","modified_gmt":"2025-07-23T12:08:55","slug":"jupiter-neurosciences-highlights-critical-advancement-of-jotrol-over-traditional-resveratrol-with-breakthrough-bioavailability-and-cns-targeted-science","status":"publish","type":"post","link":"https:\/\/english.saigonbiz.com\/vn\/jupiter-neurosciences-highlights-critical-advancement-of-jotrol-over-traditional-resveratrol-with-breakthrough-bioavailability-and-cns-targeted-science\/","title":{"rendered":"Jupiter Neurosciences Highlights Critical Advancement of JOTROL\u2122 Over Traditional Resveratrol with Breakthrough Bioavailability and CNS-Targeted Science"},"content":{"rendered":"<div>\n<p align=\"center\"><strong><em>Transforming a promising molecule into a clinically viable therapeutic platform<\/em><\/strong><\/p>\n<p align=\"justify\">Jupiter, Florida, July  23, 2025  (GLOBE NEWSWIRE) &#8212; Jupiter Neurosciences, Inc. (NASDAQ: JUNS) (&#8220;Jupiter&#8221; or the &#8220;Company&#8221;), a clinical-stage pharmaceutical company developing JOTROL<sup>\u2122<\/sup>, a patented resveratrol-based platform, spotlights the scientific and clinical advantages of its proprietary resveratrol platform, JOTROL<sup>\u2122<\/sup>, over conventional resveratrol formulations.<\/p>\n<p><strong>Unlocking Resveratrol\u2019s Therapeutic Promise<\/strong><\/p>\n<p align=\"justify\">Resveratrol is one of the world\u2019s most researched molecules and has long been studied for its powerful antioxidant, mitochondrial, and anti-inflammatory effects. However, achieving therapeutic benefit has proven elusive due to the molecule\u2019s extremely poor bioavailability and dose-limiting gastrointestinal (GI) side effects.<\/p>\n<p align=\"justify\">\u201cClinical studies have shown that to reach the minimum effective plasma concentration of over 250 ng\/mL a patient would need to ingest approximately 5 grams of today\u2019s marketed resveratrol products,\u201d explained Christer Ros\u00e9n, Chairman and CEO of Jupiter Neurosciences. \u201cAt those levels, severe GI issues are nearly guaranteed, effectively halting any realistic therapeutic use.\u201d<\/p>\n<p><strong>A Pharmaceutical-Grade Breakthrough<\/strong><\/p>\n<p align=\"justify\">JOTROL<sup>\u2122<\/sup> was developed specifically to overcome these critical limitations. In a Phase I clinical trial, JOTROL<sup>\u2122<\/sup> achieved a nine-fold increase in bioavailability compared to traditional resveratrol, without the GI toxicity seen at high doses. This proprietary formulation enables systemic therapeutic dosing with significantly reduced pill burden and enhanced tolerability.<\/p>\n<p><strong>Key Differentiators:<\/strong><\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify;\">Approximately 9 times higher bioavailability at peak plasma concentration versus na\u00efve resveratrol<\/li>\n<li style=\"text-align:justify;\">No GI side effects observed at therapeutic levels<\/li>\n<li style=\"text-align:justify;\">Secured intellectual property in the U.S., EU, China, Japan, and Hong Kong through 2036<\/li>\n<li style=\"text-align:justify;\">Demonstrated ability to reach the central nervous system by passing the blood brain barrier, a critical factor for diseases such as Parkinson\u2019s, Alzheimer\u2019s, and MELAS<\/li>\n<\/ul>\n<p><strong>A Platform for Clinical Development and Commercial Growth<\/strong><\/p>\n<p align=\"justify\">JOTROL<sup>\u2122<\/sup> is currently advancing toward a Phase IIa trial in Parkinson\u2019s Disease, following breakthrough preclinical data in a well-established MPTP mouse model that demonstrated meaningful improvements in motor functions. The same delivery technology is also being used in Jupiter\u2019s Nugevia<sup>\u2122<\/sup> consumer product line, launching in Q3 2025 with targeted formulations focused on cognitive health (MND), mitochondrial energy (PWR), and skin vitality (GLO).<\/p>\n<p align=\"justify\">\u201cThis is more than just a formulation. It\u2019s a platform,\u201d added Ros\u00e9n. \u201cWhether through pharmaceutical trials or premium consumer offerings, JOTROL<sup>\u2122<\/sup> opens entirely new pathways to address CNS diseases and longevity using the same foundational science.\u201d<\/p>\n<p><strong>Scientific Rationale: Targeting Mitochondria and Inflammation<\/strong><\/p>\n<p align=\"justify\">As shown in Jupiter\u2019s preclinical and mechanistic studies, resveratrol, and by extension JOTROL<sup>\u2122<\/sup>, works by promoting mitochondrial biogenesis through AMPK and SIRT1 activation. It also scavenges oxidative radicals and suppresses neuroinflammation. These mechanisms are increasingly recognized as central to the progression of neurodegenerative disease and systemic aging.<\/p>\n<p><strong>About Jupiter Neurosciences, Inc.<\/strong><\/p>\n<p align=\"justify\">Jupiter Neurosciences is a clinical-stage pharmaceutical company pursuing a dual-path strategy to address neuroinflammation and promote healthy aging. The Company is advancing a therapeutic pipeline targeting central nervous system (CNS) disorders and rare diseases, while also expanding into the consumer longevity market with its Nugevia<sup>\u2122<\/sup> product line. Both efforts are powered by JOTROL<sup>\u2122<\/sup>, Jupiter\u2019s proprietary, enhanced resveratrol formulation that has demonstrated significantly improved bioavailability. Nugevia brings clinical-grade science to the supplement space, supporting mental clarity, skin health, and mitochondrial function. The Company\u2019s prescription pipeline is focused broadly on CNS disorders, presently with a Phase IIa in Parkinson\u2019s disease, includeing indications such as Alzheimer\u2019s Disease, Mucopolysaccharidoses Type I, Friedreich\u2019s Ataxia, and MELAS. More information may be found on the Company\u2019s website\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=5CeJ2QjZkkMs2zgYZ1cpSqhWdoIrKy7m94e6Xm9YFagDRys4nlomzQvacpsftV_Bhc69ob2N9YgYm0fP4CHs5lPPT0oVDMS915xAFoR6TSL1vWWZ92LISgXyrm0VFaK9\" rel=\"nofollow\" target=\"_blank\" title=\"www.jupiterneurosciences.com\">www.jupiterneurosciences.com<\/a>.<\/p>\n<p><strong>About JOTROL <\/strong><\/p>\n<p align=\"justify\">Resveratrol is one of the world\u2019s most extensively researched molecules. Thorough evaluation has shown that for the compound to be effective, it requires a high C-Max (~300 ng\/ml of resveratrol in plasma), achievable only with doses exceeding 3 grams using earlier resveratrol products. Poor bioavailability has been a well-documented issue with resveratrol. Doses over 2 grams have been associated with severe gastrointestinal (GI) side effects, which have prevented the compound from receiving regulatory approval for any indication.<\/p>\n<p align=\"justify\">Jupiter Neurosciences (JUNS) conducted a Phase I study demonstrating that JOTROL<sup>\u2122<\/sup> achieves over nine times higher bioavailability compared to resveratrol used in earlier clinical trials (e.g., Turner et al., MCI\/Early Alzheimer\u2019s Disease trial, and Yui et al., Friedreich\u2019s Ataxia trial). The results of this Phase I study, which will be cross-referenced in all upcoming JOTROL<sup>\u2122<\/sup> trials, were published in the Journal of Alzheimer\u2019s Disease and AAPS Open in February 2022. JUNS is now advancing JOTROL<sup>\u2122<\/sup> toward a Phase IIa trial in Parkinson\u2019s Disease.<\/p>\n<p><strong>About Nugevia<\/strong><\/p>\n<p align=\"justify\">In addition to its therapeutic applications, JOTROL<sup>\u2122<\/sup> serves as the foundation for Jupiter\u2019s Nugevia<sup>\u2122<\/sup> consumer supplement line. By leveraging the same clinically validated delivery technology, Nugevia<sup>\u2122<\/sup> introduces pharmaceutical-grade bioavailability into the wellness space, offering targeted support for cognitive health, skin vitality, and cellular energy.<\/p>\n<p>The Nugevia product line will be launched in Q3 of 2025 through the website Nugevia.com.<\/p>\n<p><strong>FORWARD-LOOKING STATEMENTS<\/strong><\/p>\n<p align=\"justify\">Certain statements in this announcement are forward-looking statements. These forward-looking statements involve known and unknown risks and uncertainties and are based on the Company\u2019s current expectations, including the Company\u2019s ability to generate revenues from the sale of JOTROL products to consumers through the DTC model. Investors can find many (but not all) of these statements by the use of words such as \u201capproximates,\u201d \u201cbelieves,\u201d \u201chopes,\u201d \u201cexpects,\u201d \u201canticipates,\u201d \u201cestimates,\u201d \u201cprojects,\u201d \u201cintends,\u201d \u201cplans,\u201d \u201cwill,\u201d \u201cwould,\u201d \u201cshould,\u201d \u201ccould,\u201d \u201cmay\u201d or other similar expressions. Although the Company believes that the expectations expressed in these forward-looking statements are reasonable, it cannot assure you that such expectations will turn out to be correct. The Company cautions investors that actual results may differ materially from the anticipated results and encourages investors to read the risk factors contained in the Company\u2019s final prospectus and other reports it files with the SEC before making any investment decisions regarding the Company\u2019s securities. The Company undertakes no obligation to update or revise publicly any forward-looking statements to reflect subsequent occurring events or circumstances, or changes in its expectations, except as may be required by law.<\/p>\n<p><strong>Contact: <\/strong><br \/>Dave Gentry<br \/>RedChip Companies, Inc.<br \/>1-407-644-4256<br \/>1-800-RED-CHIP (733-2447)<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=1zOuTYs22kAv2oMGxfjFiy3SaldjYrX2_UU-k7BUMTDi84u7LPpyV_YAKLh7CKFEeGxQA46A8Iomrynor8hxJ54boFLVHK9cLDY1i6cRNl0=\" rel=\"nofollow\" target=\"_blank\" title=\"JUNS@redchip.com\">JUNS@redchip.com<\/a><\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/MzI2ZjFkMzUtOWVjMi00YWNkLWIxNzMtYzQyZjQ4NmNkMjk0LTUwMDEzMDYzOS0yMDI1LTA3LTIzLWVu\/tiny\/Jupiter-Neurosciences-Inc-.png\" referrerpolicy=\"no-referrer-when-downgrade\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Transforming a promising molecule into a clinically viable therapeutic platform Jupiter, Florida, July 23, 2025 (GLOBE NEWSWIRE) &#8212; Jupiter Neurosciences, Inc. (NASDAQ: JUNS) (&#8220;Jupiter&#8221; or the &#8220;Company&#8221;), a clinical-stage pharmaceutical company developing JOTROL\u2122, a patented resveratrol-based platform, spotlights the scientific and clinical advantages of its proprietary resveratrol platform, JOTROL\u2122, over conventional resveratrol formulations. Unlocking Resveratrol\u2019s [&#8230;]\n","protected":false},"author":1,"featured_media":70222,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-70221","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.6 (Yoast SEO v21.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Jupiter Neurosciences Highlights Critical Advancement of JOTROL\u2122 Over Traditional Resveratrol with Breakthrough Bioavailability and CNS-Targeted Science - Biz and Live in Saigon<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/english.saigonbiz.com\/vn\/jupiter-neurosciences-highlights-critical-advancement-of-jotrol-over-traditional-resveratrol-with-breakthrough-bioavailability-and-cns-targeted-science\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jupiter Neurosciences Highlights Critical Advancement of JOTROL\u2122 Over Traditional Resveratrol with Breakthrough Bioavailability and CNS-Targeted Science\" \/>\n<meta property=\"og:description\" content=\"Transforming a promising molecule into a clinically viable therapeutic platform Jupiter, Florida, July 23, 2025 (GLOBE NEWSWIRE) &#8212; Jupiter Neuro\" \/>\n<meta property=\"og:url\" content=\"https:\/\/english.saigonbiz.com\/vn\/jupiter-neurosciences-highlights-critical-advancement-of-jotrol-over-traditional-resveratrol-with-breakthrough-bioavailability-and-cns-targeted-science\/\" \/>\n<meta property=\"og:site_name\" content=\"Biz and Live in Saigon\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SaigonbizGroup\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-23T12:08:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2025\/07\/Jupiter-Neurosciences-Inc-.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1\" \/>\n\t<meta property=\"og:image:height\" content=\"1\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/jupiter-neurosciences-highlights-critical-advancement-of-jotrol-over-traditional-resveratrol-with-breakthrough-bioavailability-and-cns-targeted-science\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/jupiter-neurosciences-highlights-critical-advancement-of-jotrol-over-traditional-resveratrol-with-breakthrough-bioavailability-and-cns-targeted-science\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/267b348e6cf32a66aab33637c2d399a6\"},\"headline\":\"Jupiter Neurosciences Highlights Critical Advancement of JOTROL\u2122 Over Traditional Resveratrol with Breakthrough Bioavailability and CNS-Targeted Science\",\"datePublished\":\"2025-07-23T12:08:55+00:00\",\"dateModified\":\"2025-07-23T12:08:55+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/jupiter-neurosciences-highlights-critical-advancement-of-jotrol-over-traditional-resveratrol-with-breakthrough-bioavailability-and-cns-targeted-science\/\"},\"wordCount\":1014,\"publisher\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#organization\"},\"articleSection\":[\"Pr Newswire\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/jupiter-neurosciences-highlights-critical-advancement-of-jotrol-over-traditional-resveratrol-with-breakthrough-bioavailability-and-cns-targeted-science\/\",\"url\":\"https:\/\/english.saigonbiz.com\/vn\/jupiter-neurosciences-highlights-critical-advancement-of-jotrol-over-traditional-resveratrol-with-breakthrough-bioavailability-and-cns-targeted-science\/\",\"name\":\"Jupiter Neurosciences Highlights Critical Advancement of JOTROL\u2122 Over Traditional Resveratrol with Breakthrough Bioavailability and CNS-Targeted Science - 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