{"id":73620,"date":"2025-10-30T12:04:13","date_gmt":"2025-10-30T12:04:13","guid":{"rendered":"https:\/\/english.saigonbiz.com.vn\/2025\/10\/30\/t-knife-therapeutics-announces-four-upcoming-data-presentations-on-prame-targeted-tk-6302-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/"},"modified":"2025-10-30T12:04:13","modified_gmt":"2025-10-30T12:04:13","slug":"t-knife-therapeutics-announces-four-upcoming-data-presentations-on-prame-targeted-tk-6302-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting","status":"publish","type":"post","link":"https:\/\/english.saigonbiz.com\/vn\/t-knife-therapeutics-announces-four-upcoming-data-presentations-on-prame-targeted-tk-6302-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/","title":{"rendered":"T-knife Therapeutics Announces Four Upcoming Data Presentations on PRAME-Targeted TK-6302 at the Society for Immunotherapy of Cancer (SITC) Annual Meeting"},"content":{"rendered":"
\n

— Posters will review product characterization and manufacturing data on T-knife\u2019s lead program, TK-6302, a supercharged PRAME T cell receptor therapy that is advancing towards the clinic, with the filing of a Clinical Trial Application planned in Q4 2025\u00a0<\/em><\/p>\n

— PRAME is a validated target and is expressed in cancers of the skin, uterus, ovaries, lungs, breasts, esophagus, kidneys, cervix, and head & neck<\/em><\/p>\n

SAN FRANCISCO and BERLIN, Oct. 30, 2025 (GLOBE NEWSWIRE) — T-knife Therapeutics, Inc., a biopharmaceutical company developing T cell receptor (TCR) engineered T cell therapies (TCR-T) to fight cancer, today announced that four posters on TK-6302 will be presented at the upcoming Society for Immunotherapy of Cancer (SITC) Annual Meeting taking place November 7-9, 2025, in National Harbor, MD.<\/p>\n

\u201cWe are excited by our strong presence at this leading immunotherapy congress where several datasets on TK-6302, our supercharged PRAME TCR-T, will be featured,\u201d stated Peggy Sotiropoulou, Ph.D., Chief Scientific Officer of T-knife. \u201cThese data highlight the innovative engineering advances underpinning TK-6302 with the aim of broadening the clinical benefit of T cell therapy across diverse solid tumor cancers. By addressing key barriers such as T-cell fatigue, limited persistence, and an immunosuppressive tumor microenvironment, our approach is designed to generate more durable and meaningful responses for patients. It is an exciting time to be at the forefront of technological innovation, driving the next generation of transformative solutions in cancer immunotherapy.\u201d<\/p>\n

Poster Presentation Details<\/strong><\/p>\n\n\n\n\n\n
Title:<\/td>\nAnalysis of PRAME in advanced \/ metastatic solid tumors shows homogeneous expression, and stability between lesions, across treatment lines and upon exposure to checkpoint inhibitors<\/td>\n<\/tr>\n
Abstract Number:<\/td>\n27<\/td>\n<\/tr>\n
Date:<\/td>\nFriday, November 7<\/td>\n<\/tr>\n
Time:<\/td>\n10:00 a.m. \u2013 7:00 p.m. ET<\/td>\n<\/tr>\n<\/table>\n

<\/p>\n\n\n\n\n\n
Title:<\/td>\nTK-6302, a supercharged PRAME TCR-T cell therapy containing a high affinity TCR, a costimulatory CD8 coreceptor and a FAS-based switch receptor, demonstrates preclinical safety and efficacy<\/td>\n<\/tr>\n
Abstract Number:<\/td>\n329<\/td>\n<\/tr>\n
Date:<\/td>\nFriday, November 7<\/td>\n<\/tr>\n
Time:<\/td>\n10:00 a.m. \u2013 7:00 p.m. ET<\/td>\n<\/tr>\n<\/table>\n

<\/p>\n\n\n\n\n\n
Title:<\/td>\nIn-depth characterization of TK-6302, a supercharged PRAME TCR-T therapy, manufactured at-scale from healthy donors and patients<\/td>\n<\/tr>\n
Abstract Number:<\/td>\n347<\/td>\n<\/tr>\n
Date:<\/td>\nFriday, November 7<\/td>\n<\/tr>\n
Time:<\/td>\n10:00 a.m. \u2013 7:00 p.m. ET<\/td>\n<\/tr>\n<\/table>\n

<\/p>\n\n\n\n\n\n
Title:<\/td>\nPreclinical assessment of genome editing safety in CRISPR-engineered PRAME-targeting TK-6302 TCR-T cells demonstrates editing precision and safety<\/td>\n<\/tr>\n
Abstract Number:<\/td>\n330<\/td>\n<\/tr>\n
Date:<\/td>\nSaturday, November 8<\/td>\n<\/tr>\n
Time:<\/td>\n10:00 a.m. \u2013 6:35 p.m. ET<\/td>\n<\/tr>\n<\/table>\n


About T-knife Therapeutics<\/strong>
T-knife is a biopharmaceutical company dedicated to developing T cell receptor (TCR) engineered T cell therapies (TCR-Ts) to deliver broad, deep and durable responses to solid tumor cancer patients. The company\u2019s unique approach leverages its proprietary platforms and synthetic biology capabilities to design the next-generation of supercharged TCR-Ts with best-in-class potential.<\/p>\n

The company\u2019s lead program, TK-6302, is a supercharged PRAME targeting TCR-T that includes novel enhancements to improve T cell fitness and persistence, to overcome the immunosuppressive tumor micro-environment, and to improve durability of response. The company plans to submit a Clinical Trial Application (CTA) in Q4 2025 and to initiate a Phase 1 clinical study of TK-6302 in 2026.<\/p>\n

T-knife was founded by leading T cell and immunology experts utilizing technology developed at the Max Delbr\u00fcck Center for Molecular Medicine together with Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, is led by an experienced management team, and is supported by a leading group of international investors, including Andera Partners, EQT Life Sciences, RA Capital Management and Versant Ventures. For additional information, please visit the company\u2019s website at www.t-knife.com<\/a>.<\/p>\n

T-knife Therapeutics, Inc.<\/u>\u00a0
Camille Landis\u00a0\u00a0
Chief Business Officer \/ Chief Financial Officer\u00a0
media@t-knife.com\u00a0<\/p>\n

\"\"<\/div>\n","protected":false},"excerpt":{"rendered":"

— Posters will review product characterization and manufacturing data on T-knife\u2019s lead program, TK-6302, a supercharged PRAME T cell receptor therapy that is advancing towards the clinic, with the filing of a Clinical Trial Application planned in Q4 2025\u00a0 — PRAME is a validated target and is expressed in cancers of the skin, uterus, ovaries, […]\n","protected":false},"author":1,"featured_media":73621,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-73620","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\nT-knife Therapeutics Announces Four Upcoming Data Presentations on PRAME-Targeted TK-6302 at the Society for Immunotherapy of Cancer (SITC) Annual Meeting - Biz and Live in Saigon<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/english.saigonbiz.com\/vn\/t-knife-therapeutics-announces-four-upcoming-data-presentations-on-prame-targeted-tk-6302-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T-knife Therapeutics Announces Four Upcoming Data Presentations on PRAME-Targeted TK-6302 at the Society for Immunotherapy of Cancer (SITC) Annual Meeting\" \/>\n<meta property=\"og:description\" content=\"— Posters will review product characterization and manufacturing data on T-knife\u2019s lead program, TK-6302, a supercharged PRAME T cell receptor\" \/>\n<meta property=\"og:url\" content=\"https:\/\/english.saigonbiz.com\/vn\/t-knife-therapeutics-announces-four-upcoming-data-presentations-on-prame-targeted-tk-6302-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/\" \/>\n<meta property=\"og:site_name\" content=\"Biz and Live in Saigon\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SaigonbizGroup\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-30T12:04:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2025\/10\/T-knife-Therapeutics.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1\" \/>\n\t<meta property=\"og:image:height\" content=\"1\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/t-knife-therapeutics-announces-four-upcoming-data-presentations-on-prame-targeted-tk-6302-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/t-knife-therapeutics-announces-four-upcoming-data-presentations-on-prame-targeted-tk-6302-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/267b348e6cf32a66aab33637c2d399a6\"},\"headline\":\"T-knife Therapeutics Announces Four Upcoming Data Presentations on PRAME-Targeted TK-6302 at the Society for Immunotherapy of Cancer (SITC) Annual Meeting\",\"datePublished\":\"2025-10-30T12:04:13+00:00\",\"dateModified\":\"2025-10-30T12:04:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/t-knife-therapeutics-announces-four-upcoming-data-presentations-on-prame-targeted-tk-6302-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/\"},\"wordCount\":581,\"publisher\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#organization\"},\"articleSection\":[\"Pr Newswire\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/t-knife-therapeutics-announces-four-upcoming-data-presentations-on-prame-targeted-tk-6302-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/\",\"url\":\"https:\/\/english.saigonbiz.com\/vn\/t-knife-therapeutics-announces-four-upcoming-data-presentations-on-prame-targeted-tk-6302-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/\",\"name\":\"T-knife Therapeutics Announces Four Upcoming Data Presentations on PRAME-Targeted TK-6302 at the Society for Immunotherapy of Cancer (SITC) Annual Meeting - 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