{"id":79752,"date":"2026-04-19T12:05:09","date_gmt":"2026-04-19T12:05:09","guid":{"rendered":"https:\/\/english.saigonbiz.com\/vn\/fedora-pharmaceuticals-presentations-at-2026-escmid-highlight-safety-and-potent-bactericidal-activity-of-fpi-2119\/"},"modified":"2026-04-19T12:05:09","modified_gmt":"2026-04-19T12:05:09","slug":"fedora-pharmaceuticals-presentations-at-2026-escmid-highlight-safety-and-potent-bactericidal-activity-of-fpi-2119","status":"publish","type":"post","link":"https:\/\/english.saigonbiz.com\/vn\/fedora-pharmaceuticals-presentations-at-2026-escmid-highlight-safety-and-potent-bactericidal-activity-of-fpi-2119\/","title":{"rendered":"Fedora Pharmaceuticals Presentations at 2026 ESCMID Highlight Safety and Potent Bactericidal Activity of FPI-2119"},"content":{"rendered":"<div>\n<p><em>Potent antibacterial activity against Gram-negative community and hospital-acquired infections highlighted across eight posters and two presentationS<\/em><\/p>\n<p>EDMONTON, Alberta , April  19, 2026  (GLOBE NEWSWIRE) &#8212; <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=VohkjlwMqOQLmAf07wFgqaQUwKUSs5STdRhBpyz8oFA6qUNQ173eYMAZrVhu-yw-FsPJm7abv40ak-sUZ-NGUXFToL7bgPs_9FigaNPK32GsjqOMXh0R4tzI5f3ba7Jp\" rel=\"nofollow\" target=\"_blank\" title=\"Fedora Pharmaceuticals, Inc.\">Fedora Pharmaceuticals, Inc.<\/a>, a leader in the development of drugs to treat antibiotic-resistant infections, is presenting a full suite of preclinical findings from the company\u2019s lead candidate, FPI-2119 at the European Society of Clinical Microbiology and Infectious Diseases Congress (ESCMID) in Munich, Germany. Presentations at ESCMID are authored by Fedora as well as collaborators at St. Jude Children\u2019s Research Hospital, JMI Laboratories (Part of Element), Indiana University, and Pharmacology Discovery Services (a Eurofins Discovery Partner Lab).<\/p>\n<p>ESCMID presentations will highlight the candidate\u2019s activity against some of the most difficult-to-treat Gram-negative infections, including respiratory tract infections, sexually transmitted infections, and high-mortality nosocomial infections. Many of these pathogens are in the high-priority category in the World Health Organization (WHO) Bacterial Priority Pathogens List (BPPL) due to the public health challenges they present and the limited treatment options available.<\/p>\n<p>\u201cFor decades, the medical community has relied on antibiotics to ensure the effective treatment of both hospitalized patients and those with community-acquired infections such as urinary tract infections (UTIs),\u201d explained <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=yO-M_--pLHE1WItgLQcf43kjfdLSieA7hb0Muc02kOfjXFewMC0_I9ZNyyYrYB2HnCtbZxw3MPEazF8X6MdB58E96BXIdL-JN1N428B8_E5-h7hroEXXs2j2OTiwUsWyH-3nhD8Q5AG5QirjJdTblA==\" rel=\"nofollow\" target=\"_blank\" title=\"Karen Bush, Ph.D.\">Karen Bush, Ph.D.<\/a>, Indiana University professor emerita and member of the Fedora scientific advisory board. \u201cResearch into new antibacterial agents is very limited in spite of the fact that pathogens continue to evolve new resistance mechanisms. Every year increasing treatment failures occur to previously reliable antibacterial agents. This puts hospital patients and the greater community at serious risk of succumbing to infections that were once easily treatable. The data being presented at ESCMID show that FPI-2119 has the potential to become a valuable tool to fight today\u2019s infectious diseases.\u201d<\/p>\n<p>Fedora\u2019s poster presentations at ESCMID highlight the following findings from preclinical studies of FPI-2119:<\/p>\n<ul>\n<li style=\"margin-top:0in; margin-bottom:0in;\">Concentration-dependent bactericidal activity and low frequency of resistance against <i>Pseudomonas aeruginosa<\/i> (Poster 2568)<\/li>\n<li style=\"margin-top:0in; margin-bottom:0in;\">Maintenance of activity against <i>Escherichia coli<\/i> strains carrying a broad range of potent \u03b2-lactamase encoding genes, confirming its stability in the presence of this resistance mechanism (Poster 2580)<\/li>\n<li style=\"margin-top:0in; margin-bottom:0in;\">Activity against a collection of bacterial isolates, including resistant strains of <i>Campylobacter<\/i>, <i>Salmonella<\/i>, and <i>Shigella<\/i>, as well as <i>Haemophilus influenzae<\/i> and <i>Moraxella catarrhalis<\/i>, which are commonly associated with intestinal and respiratory tract infections (Poster 2581)<\/li>\n<li style=\"margin-top:0in; margin-bottom:0in;\">Potency against all strains of <i>N.<\/i> <i>gonorrhoeae <\/i>including six that are resistant to penicillin, tetracycline, and ciprofloxacin, three of which exhibit reduced susceptibility to ceftriaxone (Poster 2583)<\/li>\n<li style=\"margin-top:0in; margin-bottom:0in;\">No measurable cardiotoxicity and clean off-target safety profile (Poster 2599)<\/li>\n<li style=\"margin-top:0in; margin-bottom:0in;\">Potency at comparable or lower concentrations than cefepime to treat multidrug-resistant strains of <i>P. aeruginosa<\/i>, <i>E. coli<\/i>, and <i>Klebsiella pneumoniae <\/i>(Poster 2601)<\/li>\n<li style=\"margin-top:0in; margin-bottom:0in;\">Statistically significant and dose-dependent reductions in bacterial burden in bladder and kidney in a mouse model of complicated UTI (Poster 2643)<\/li>\n<li style=\"margin-top:0in; margin-bottom:0in;\">Half-life and plasma concentrations predictive of BID (twice a day) or QD (once a day) dosing in humans <i>\u00a0<\/i>(Poster 2801)<\/li>\n<\/ul>\n<p>\u201cOur first pipeline candidate, nacubactam, is a \u03b2-lactamase inhibitor with the potential to restore bactericidal activity to \u03b2-lactam antibiotics,\u201d stated <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=lXBwX0Dss9HYpPevi_s3C8TQ9cfrEA7KKkCAKIIQbfMTQW17X4_XLu-hab8wyR1S2_YmGagEb6M3G2V9vcpE7e5w6wfrQ4sg2NURPpq_ah9KbCc5i4n33qbmXzA0aEnu\" rel=\"nofollow\" target=\"_blank\" title=\"Christopher Micetich\">Christopher Micetich<\/a>, chief executive officer and founder of Fedora Pharmaceuticals. \u201cFPI-2119, our second candidate, is a potent antibiotic with the potential to treat infections caused by pathogens that produce \u03b2-lactamases. Together, these candidates offer innovative strategies to address the urgent need to treat resistant infections.\u201d<\/p>\n<p><b>About FPI-2119<br \/><\/b>FPI-2119, a first-in-kind derivative of the lactivicin class, is in development for the treatment of Gram-negative infections. As a non-\u03b2-lactam antibiotic, FPI-2119 lacks the classical ring structure that defines that class. It is therefore not expected to be susceptible to \u03b2-lactamases, a resistance mechanism bacteria have developed to thwart \u03b2-lactam antibiotics such as cefepime. FPI-2119 has demonstrated a broad spectrum of activity against multiple Gram-negative pathogens including\u00a0<i>Pseudomonas aeruginosa<\/i>, <i>Acinetobacter baumannii<\/i>, Enterobacterales, and other clinically significant pathogens. Target indications include complicated hospital-acquired and ventilator-associated bacterial pneumonia (cHABP\/cVABP), complicated urinary tract infections (cUTI), and complicated intra-abdominal infections (cIAI).<\/p>\n<p><b>About Fedora Pharmaceuticals<\/b><br \/>Fedora Pharmaceuticals Inc. is an innovative biotech founded in 2011 and headquartered in Edmonton, Alberta, Canada. The company is dedicated to discovering and developing novel antimicrobial drugs to tackle antibiotic resistance (AMR). With a strong <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=HDGrGo3kLQqEO6ZQ_zFl4JnxOkNNJ1mn3pJZgQgmDv526i6dBO81FbAbKEQU8P_gA6Om9aufNXuWgGQi3J69QXkTYv6H2dK-AUh-8-pCGJw=\" rel=\"nofollow\" target=\"_blank\" title=\"pipeline\">pipeline<\/a> and expert scientific team, Fedora\u2019s mission is to deliver solutions that impact global health. Fedora\u2019s most advanced candidate is nacubactam, a Phase 3-ready \u03b2-lactamase inhibitor being advanced with partner, Meiji Seika. Fedora holds key US rights to nacubactam. Fedora is seeking development partners for nacubactam in the US. For more information, please visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=YiP9q3tZbpKdZOyJFnjeBOpnjNOnIk98e1iA1pHHEDI_pCBm5rcv5KljJwy_mlIQc0adpsUwWHWCODjsKweuI47IUWrCQinjcIpmM3IEjp0=\" rel=\"nofollow\" target=\"_blank\" title=\"www.fedorapharma.com\">www.fedorapharma.com<\/a>.<\/p>\n<p><b>About St. Jude Children&#8217;s Research Hospital<\/b><br \/>St. Jude Children\u2019s Research Hospital is leading the way the world understands, treats, and cures childhood catastrophic diseases. From cancer to life-threatening blood disorders, neurological conditions, and infectious diseases, St. Jude is dedicated to advancing cures and means of prevention through groundbreaking research and compassionate care. Through global collaborations and innovative science, St. Jude is working to ensure that every child, everywhere, has the best chance at a healthy future. To learn more, visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=8MjA-1NGsNXLvYIj1prIfL6k645ImchBusEO_3DMwvY8xHlooom0vd_cuCo4yOFtxZacaCr9BfiFzdXUxQV8Lg==\" rel=\"nofollow\" target=\"_blank\" title=\"stjude.org\">stjude.org<\/a>, read <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=PSa7yiScmgGhWvSdbGNy78CWYVhRRvzHG_mNYQYL-HBEeqKDWFKY_EFTKbiY-3Z4h8GwYn6QEY_ohLZfpjXcOWLtCV1nTvNx9O8W9LR2p6bofn3LG-CGS7Mw51G7PUPu\" rel=\"nofollow\" target=\"_blank\" title=\"\"><i>St. Jude Progress<\/i><\/a>, a digital magazine, or contact St. Jude at media@stjude.org.<\/p>\n<pre>CONTACT: Media and Investors:\r\ninfo@fedorapharma.com<\/pre>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/ZDI5YzgwYmQtMGI3My00ZGZjLThmZDMtYTIyN2ZmZjZlMjgzLTEzMTk4MzgtMjAyNi0wNC0xOS1lbg==\/tiny\/Fedora-Pharmaceuticals-Inc-.png\" referrerpolicy=\"no-referrer-when-downgrade\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Potent antibacterial activity against Gram-negative community and hospital-acquired infections highlighted across eight posters and two presentationS EDMONTON, Alberta , April 19, 2026 (GLOBE NEWSWIRE) &#8212; Fedora Pharmaceuticals, Inc., a leader in the development of drugs to treat antibiotic-resistant infections, is presenting a full suite of preclinical findings from the company\u2019s lead candidate, FPI-2119 at the [&#8230;]\n","protected":false},"author":1,"featured_media":79753,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-79752","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.6 (Yoast SEO v21.6) - 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