{"id":82624,"date":"2026-07-10T00:04:54","date_gmt":"2026-07-10T00:04:54","guid":{"rendered":"https:\/\/english.saigonbiz.com\/vn\/canadas-drug-agency-issues-positive-reimbursement-recommendation-for-empaveli-pegcetacoplan-for-the-treatment-of-c3g-and-primary-ic-mpgn\/"},"modified":"2026-07-10T00:04:54","modified_gmt":"2026-07-10T00:04:54","slug":"canadas-drug-agency-issues-positive-reimbursement-recommendation-for-empaveli-pegcetacoplan-for-the-treatment-of-c3g-and-primary-ic-mpgn","status":"publish","type":"post","link":"https:\/\/english.saigonbiz.com\/vn\/canadas-drug-agency-issues-positive-reimbursement-recommendation-for-empaveli-pegcetacoplan-for-the-treatment-of-c3g-and-primary-ic-mpgn\/","title":{"rendered":"Canada\u2019s Drug Agency Issues Positive Reimbursement Recommendation for EMPAVELI\u00ae (pegcetacoplan) for the Treatment of C3G and Primary IC-MPGN"},"content":{"rendered":"
\n

This recommendation represents an important step towards improving access for Canadians living with rare kidney diseases<\/em><\/p>\n

WALTHAM, Mass., July 09, 2026 (GLOBE NEWSWIRE) — Swedish Orphan Biovitrum AB (publ)<\/a>\u00a0(Sobi™) (STO:SOBI) is pleased to announce that Canada\u2019s Drug Agency (CDA) has issued a positive reimbursement recommendation with conditions for PrEMPAVELI\u00ae<\/sup> (pegcetacoplan) for the treatment of adult and adolescent patients aged 12 years and older with C3 glomerulopathy (C3G) or primary immune-complex membranoproliferative glomerulonephritis (IC-MPGN) to reduce proteinuria.<\/p>\n

EMPAVELI\u00ae<\/sup> is the first treatment authorized in Canada for C3G or primary IC-MPGN. The positive recommendation from CDA marks an important milestone in the reimbursement process for public drug plans across Canada.<\/p>\n

\u201cCDA\u2019s positive reimbursement recommendation for EMPAVELI\u00ae<\/sup> is encouraging news for Canadians living with C3G and primary IC-MPGN, two rare and serious kidney diseases with significant unmet need,\u201d said Bob McLay, Vice President and General Manager, Sobi Canada. \u201cThis recommendation reflects the importance of improving access to innovative therapies for patients and families who have historically faced limited treatment options and a high risk of disease progression and kidney failure.\u201d<\/p>\n

The CDA recommendation was informed by data from the Phase 3 VALIANT study, the largest single clinical trial conducted in patients with C3G and primary IC-MPGN. The study evaluated pegcetacoplan in 124 patients aged 12 years and older and demonstrated clinically meaningful reductions in proteinuria, stabilization of kidney function, and clearance of C3 deposits.<\/p>\n

\u201cPatients living with C3G and primary IC-MPGN face significant uncertainty due to the progressive nature of these diseases and the lack of disease modifying treatment options historically available\u201d said Dr. Christoph Licht, Head, Division of Nephrology, SickKids, The Hospital for Sick Children, Toronto. \u201cA positive reimbursement recommendation for EMPAVELI\u00ae<\/sup> is an important step toward helping eligible patients access a therapy specifically designed to target the underlying complement-mediated disease process.\u201d<\/p>\n

C3G and primary IC-MPGN are rare kidney diseases driven by uncontrolled activation of the complement system, leading to inflammation and kidney damage. Approximately 50 percent of people living with these diseases experience kidney failure within five to 10 years of diagnosis, often requiring dialysis or kidney transplantation. Disease recurrence following transplant is also common. 1-3<\/sup><\/p>\n

EMPAVELI\u00ae (pegcetacoplan) is a targeted C3 and C3b therapy designed to regulate excessive activation of the complement cascade, part of the body\u2019s immune system, which can lead to the onset and progression of many serious diseases.<\/p>\n

Following CDA\u2019s recommendation, reimbursement discussions with participating public drug plans will proceed through the pan-Canadian Pharmaceutical Alliance (pCPA).<\/p>\n

About C3\u00a0Glomerulopathy (C3G) and\u00a0Primary Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN)<\/strong>
C3G and primary IC-MPGN are rare and debilitating kidney diseases that can lead to kidney failure. Excessive C3 deposits are a key marker of disease activity, which can lead to kidney inflammation, damage, and failure. Approximately 50% of people living with C3G or primary IC-MPGN suffer from kidney failure within five to 10 years of diagnosis, requiring a burdensome kidney transplant or dialysis therapy.1-3<\/sup>\u00a0Additionally, approximately 90% of patients who previously received a kidney transplant will experience disease recurrence.4<\/sup>\u00a0The diseases are estimated to affect 5,000 people in the United States and up to 8,000 in Europe.5<\/sup>\u00a0<\/p>\n

\u00a0About the VALIANT Study<\/strong>
The VALIANT Phase 3 study (NCT05067127) was a randomized, placebo-controlled, double-blinded, multi-center study that evaluated pegcetacoplan efficacy and safety in 124 patients who were 12 years of age and older with C3G or primary IC-MPGN. It is the largest single trial conducted in these populations and the only study to include pediatric and adult patients, with native and post-transplant kidneys. Study participants were randomized to receive pegcetacoplan or placebo twice weekly for 26 weeks. Following this 26-week randomized controlled period, patients were able to proceed to a 26-week open-label phase in which all patients received pegcetacoplan. The primary endpoint of the study was the log transformed ratio of urine protein-to-creatinine ratio (UPCR) at Week 26 compared to baseline.
\u00a0<\/strong>
About EMPAVELI\u00ae<\/sup> (pegcetacoplan<\/strong>)
EMPAVELI\u00ae<\/sup> (pegcetacoplan) is a targeted C3 and C3b therapy designed to regulate excessive activation of the complement cascade, part of the body\u2019s immune system, which can lead to the onset and progression of many serious diseases. It is the first treatment for C3 glomerulopathy (C3G) or primary immune complex membranoproliferative glomerulonephritis (IC-MPGN) in patients 12 years of age and older approved in the United States, European Union, Canada and other countries globally.<\/p>\n

EMPAVELI\u00ae<\/sup> is also approved for the treatment of adults with paroxysmal nocturnal hemoglobinuria (PNH) in Canada, the United States, European Union, and other countries globally.
\u00a0
About the Sobi\u00ae<\/sup> and Apellis Collaboration<\/strong>
Apellis and Sobi have global co-development rights for systemic pegcetacoplan. Sobi has exclusive non-U.S. commercialization rights for systemic pegcetacoplan. Apellis has exclusive U.S. commercialization rights for systemic pegcetacoplan and worldwide commercial rights for ophthalmological pegcetacoplan, including for geographic atrophy.<\/p>\n

Sobi\u00ae<\/sup><\/strong>
Sobi is a global biopharma company unlocking the potential of breakthrough innovations, transforming everyday life for people living with rare diseases.\u00a0Sobi has approximately 1,900 employees across Europe, North America, the Middle East, Asia and Australia. In 2025, revenue amounted to SEK 28 billion. Sobi\u2019s share (STO:SOBI) is listed on Nasdaq Stockholm. More about Sobi at\u00a0sobi.com<\/a>\u00a0and\u00a0LinkedIn<\/a>.
\u00a0<\/strong>
Contacts<\/strong>
For details on how to contact the Sobi Investor Relations Team, please click\u00a0here<\/a>. For Sobi Media contacts, click\u00a0here<\/a>.<\/p>\n

\u00a0<\/strong>References<\/strong><\/p>\n

1. Smith RJH, et al. Nat Rev Nephrol. 2019;15(3):129-143.
2. Servais A, et al. Kidney Int. 2012;82(4):454-464.
3. Zand L, et al. J Am Soc Nephrol. 2014;25(5):1110-1117.
4. Tarrag\u00f3n, B, et al. Clin J Am Soc Nephrol 2024; 19(8)1005-1015.
5. Data on file using literature consensus.
6. Fakhouri F, et al. N Engl J Med 2025;393:2210-2220
7. Nester C. et al., Clin J Am Soc Nephrol 2024 19(9:1201-1208.<\/p>\n

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This recommendation represents an important step towards improving access for Canadians living with rare kidney diseases WALTHAM, Mass., July 09, 2026 (GLOBE NEWSWIRE) — Swedish Orphan Biovitrum AB (publ)\u00a0(Sobi™) (STO:SOBI) is pleased to announce that Canada\u2019s Drug Agency (CDA) has issued a positive reimbursement recommendation with conditions for PrEMPAVELI\u00ae (pegcetacoplan) for the treatment of adult […]\n","protected":false},"author":1,"featured_media":85254,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-82624","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-people"],"yoast_head":"\nCanada\u2019s Drug Agency Issues Positive Reimbursement Recommendation for EMPAVELI\u00ae (pegcetacoplan) for the Treatment of C3G and Primary IC-MPGN - Biz and Live in Saigon<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/english.saigonbiz.com\/vn\/canadas-drug-agency-issues-positive-reimbursement-recommendation-for-empaveli-pegcetacoplan-for-the-treatment-of-c3g-and-primary-ic-mpgn\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Canada\u2019s Drug Agency Issues Positive Reimbursement Recommendation for EMPAVELI\u00ae (pegcetacoplan) for the Treatment of C3G and Primary IC-MPGN\" \/>\n<meta property=\"og:description\" content=\"This recommendation represents an important step towards improving access for Canadians living with rare kidney diseases WALTHAM, Mass., July 09, 2026\" \/>\n<meta property=\"og:url\" content=\"https:\/\/english.saigonbiz.com\/vn\/canadas-drug-agency-issues-positive-reimbursement-recommendation-for-empaveli-pegcetacoplan-for-the-treatment-of-c3g-and-primary-ic-mpgn\/\" \/>\n<meta property=\"og:site_name\" content=\"Biz and Live in Saigon\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SaigonbizGroup\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-10T00:04:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/english.saigonbiz.com\/vn\/wp-content\/uploads\/2026\/05\/SaigonBiz-Feature-Image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1074\" \/>\n\t<meta property=\"og:image:height\" content=\"716\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/canadas-drug-agency-issues-positive-reimbursement-recommendation-for-empaveli-pegcetacoplan-for-the-treatment-of-c3g-and-primary-ic-mpgn\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/canadas-drug-agency-issues-positive-reimbursement-recommendation-for-empaveli-pegcetacoplan-for-the-treatment-of-c3g-and-primary-ic-mpgn\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#\/schema\/person\/267b348e6cf32a66aab33637c2d399a6\"},\"headline\":\"Canada\u2019s Drug Agency Issues Positive Reimbursement Recommendation for EMPAVELI\u00ae (pegcetacoplan) for the Treatment of C3G and Primary IC-MPGN\",\"datePublished\":\"2026-07-10T00:04:54+00:00\",\"dateModified\":\"2026-07-10T00:04:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/canadas-drug-agency-issues-positive-reimbursement-recommendation-for-empaveli-pegcetacoplan-for-the-treatment-of-c3g-and-primary-ic-mpgn\/\"},\"wordCount\":950,\"publisher\":{\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/#organization\"},\"articleSection\":[\"People\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/english.saigonbiz.com\/vn\/canadas-drug-agency-issues-positive-reimbursement-recommendation-for-empaveli-pegcetacoplan-for-the-treatment-of-c3g-and-primary-ic-mpgn\/\",\"url\":\"https:\/\/english.saigonbiz.com\/vn\/canadas-drug-agency-issues-positive-reimbursement-recommendation-for-empaveli-pegcetacoplan-for-the-treatment-of-c3g-and-primary-ic-mpgn\/\",\"name\":\"Canada\u2019s Drug Agency Issues Positive Reimbursement Recommendation for EMPAVELI\u00ae (pegcetacoplan) for the Treatment of C3G and Primary IC-MPGN - 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